Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MET | P08581 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.38 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.37 |
| ▸ | CTSB | P07858 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.37 |
| ▸ | CKS1B | P61024 | 1/20 | 0.36 |
| ▸ | SKP1 | P63208 | 1/20 | 0.36 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30998112 | 0.75 | MAPT (0.63) | ALDH1A1LMNAMAPTMETENPP2 | |
| SCHEMBL4435451 | 0.75 | MAPT (0.63) | ALDH1A1LMNAMAPTMETENPP2 | |
| SCHEMBL219576 | 0.72 | ACKR3 (0.41) | ALDH1A1LMNAMAPTMETKDM4E | |
| SCHEMBL14607762 | 0.71 | TERT (0.41) | ALDH1A1LMNAMAPTMETKDM4E | |
| SCHEMBL3025284 | 0.71 | ALDH1A1 (0.45) | ALDH1A1LMNAMAPTMETKDM4E | |
| SCHEMBL18658168 | 0.70 | VEGFA (0.52) | ALDH1A1LMNAMAPTMETKDM4E | |
| SCHEMBL26603989 | 0.70 | ALDH1A1 (0.49) | ALDH1A1LMNAMAPTKDM4ECHRM2 | |
| SCHEMBL221302 | 0.69 | KMT2A (0.42) | ALDH1A1LMNAMAPTTP53KMT2A | |
| SCHEMBL23922807 | 0.69 | GRM5 (0.51) | ALDH1A1KDM4ECHRM2CHRM4CHRM1 | |
| SCHEMBL617183 | 0.69 | FAAH (0.47) | ALDH1A1MAPTKDM4ECHRM2CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910380-A1 | OXAZOLOPYRIDINE DERIVATIVES AS SIRTUIN MODULATORS | Sirtris Pharmaceuticals, Inc. (US) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007019417-A1 | OXAZOLOPYRIDINE DERIVATIVES AS SIRTUIN MODULATORS | SIRTRIS PHARMACEUTICALS, INC. (US) | 2007-02-15 | — | — | WO | disclosed |