SCHEMBL4859800

SCHEMBL4859800

COC(=O)c1ccc(C(F)(F)F)nc1CBr

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TUBB4A P04350 1/20 0.51
TUBB P07437 1/20 0.51
TUBA3C P0DPH7 1/20 0.51
TUBA1B P68363 1/20 0.51
TUBA4A P68366 1/20 0.51
TUBB4B P68371 1/20 0.51
TUBB3 Q13509 1/20 0.51
TUBB2A Q13885 1/20 0.51
TUBB8 Q3ZCM7 1/20 0.51
TUBA3E Q6PEY2 1/20 0.51
TUBA1A Q71U36 1/20 0.51
TUBA1C Q9BQE3 1/20 0.51
TUBB6 Q9BUF5 1/20 0.51
TUBB2B Q9BVA1 1/20 0.51
TUBB1 Q9H4B7 1/20 0.51
CFTR P13569 1/20 0.43
SDHB P21912 1/20 0.41
LMNA P02545 1/20 0.39
NPC1 O15118 2/20 0.39
RAB9A P51151 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4472256 0.88 TUBB4A (0.51) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL6219264 0.87 TUBB4A (0.50) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL4196998 0.85 TUBB4A (0.49) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL28110449 0.85 TUBB4A (0.49) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL1498432 0.85 KDM4E (0.46)
SCHEMBL6220030 0.83 TUBB4A (0.47) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL21223246 0.83 TUBB4A (0.47) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL12688600 0.83 LMNA (0.39) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL124080 0.81 TUBB4A (0.53) TUBB4ATUBBTUBA3CTUBA1BTUBA4A
SCHEMBL18869269 0.81 TUBB4A (0.46) TUBB4ATUBBTUBA3CTUBA1BTUBA4A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12495798-B2 Nicotinamide compound and herbicidal composition comprising compound KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 2025-12-16 US disclosed
US-20220386607-A1 NICOTINAMIDE COMPOUND AND HERBICIDAL COMPOSITION COMPRISING COMPOUND Farmhannong Co., Ltd. (KR) 2022-12-08 US disclosed
WO-2022225312-A1 OXAZOLIDINONE DERIVATIVE AND HERBICIDAL COMPOSITION COMPRISING THE COMPOUND 한국화학연구원 2022-10-27 WO disclosed
EP-4050007-A1 NICOTINAMIDE COMPOUND AND HERBICIDAL COMPOSITION COMPRISING COMPOUND Korea Research Institute of Chemical Technology (KR) 2022-08-31 EP disclosed
CN-114599644-A Nicotinamide compound and herbicide composition containing the same 韩国化学研究院 2022-06-07 CN disclosed
WO-2021080330-A1 NICOTINAMIDE COMPOUND AND HERBICIDAL COMPOSITION COMPRISING COMPOUND 한국화학연구원 2021-04-29 WO disclosed
US-7439207-B2 2,6 substituted pyridine-3-carbonyl derivatives serving as plant protection agents having herbicidal action BAYER CROPSCIENCE AG (DE) 2008-10-21 US disclosed
EP-1140845-B1 SUSBSTITUTED PYRIDINE HERBICIDES SYNGENTA PARTICIPATIONS AG (CH) 2005-02-23 EP disclosed
US-20050020451-A1 2,6 Substituted pyridine-3-carbonyl derivatives serving as plant protection agents having herbicidal action BAYER CROPSCIENCE AG (DE) 2005-01-27 US disclosed
US-6673938-B1 Substituted pyridine herbicides SYNGENTA PARTICIPATIONS AG (CH) 2004-01-06 US disclosed
US-6534445-B1 Pyridine ketones for controlling weeds SYNGENTA PARTICIPATIONS AG (CH) 2003-03-18 US disclosed
US-20030040437-A1 Substituted pyridine herbicides SYNGENTA PARTICIPATIONS AG (CH) 2003-02-27 US disclosed
EP-1140845-A1 SUSBSTITUTED PYRIDINE HERBICIDES Syngenta Participations AG (CH) 2001-10-10 EP disclosed
WO-2000039094-A1 SUBSTITUTED PYRIDINE HERBICIDES SYNGENTA PARTICIPATIONS AG (CH) 2000-07-06 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050020451-A1 2,6 Substituted pyridine-3-carbonyl derivatives serving as plant protection agents having herbicidal action PDHX, PRDX6, CBR3 TUBB4A 1149/4885TUBB 995/4885TUBA3C 606/4885
US-20030040437-A1 Substituted pyridine herbicides DDT, CYP1A1, CYP1B1 TUBB4A 370/4885TUBB 277/4885TUBA3C 228/4885
US-12495798-B2 Nicotinamide compound and herbicidal composition comprising compound NAMPT, SIRT1, SIRT6 TUBB4A 1186/4885TUBB 790/4885TUBA3C 1486/4885
US-20220386607-A1 NICOTINAMIDE COMPOUND AND HERBICIDAL COMPOSITION COMPRISING COMPOUND NAMPT, SIRT1, SIRT6 TUBB4A 1186/4885TUBB 790/4885TUBA3C 1486/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.