Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | KDM1A | O60341 | 3/20 | 0.51 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.40 |
| ▸ | EBP | Q15125 | 1/20 | 0.39 |
| ▸ | CASP6 | P55212 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12305110 | 0.89 | MEN1 (0.44) | MEN1KMT2AKDM1ASIGMAR1TP53 | |
| SCHEMBL28282552 | 0.79 | KDM1A (0.47) | MEN1KMT2AKDM1AAKR1B1SIGMAR1 | |
| SCHEMBL2091146 | 0.76 | KDM1A (0.45) | MEN1KMT2AKDM1AAKR1B1SIGMAR1 | |
| SCHEMBL27467088 | 0.75 | AKR1B1 (0.44) | MEN1KMT2AKDM1AAKR1B1SIGMAR1 | |
| SCHEMBL27635341 | 0.75 | AKR1B1 (0.44) | MEN1KMT2AKDM1AAKR1B1SIGMAR1 | |
| SCHEMBL27635358 | 0.75 | AKR1B1 (0.44) | MEN1KMT2AKDM1AAKR1B1SIGMAR1 | |
| SCHEMBL6495897 | 0.75 | KDM1A (0.51) | MEN1KMT2AKDM1AAKR1B1SIGMAR1 | |
| SCHEMBL578812 | 0.75 | KDM1A (0.59) | MEN1KMT2AKDM1AAKR1B1SIGMAR1 | |
| SCHEMBL29556050 | 0.75 | KDM1A (0.59) | MEN1KMT2AKDM1AAKR1B1SIGMAR1 | |
| SCHEMBL19577941 | 0.75 | KDM1A (0.47) | MEN1KMT2AKDM1AAKR1B1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10233146-B2 | Acetylenic cyanoenones as therapeutics for inflammation and carcinogenesis | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) | 2019-03-19 | — | — | US | disclosed |
| US-10233146-B2 | Acetylenic cyanoenones as therapeutics for inflammation and carcinogenesis | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) | 2019-03-19 | — | — | US | disclosed |
| US-20180134654-A1 | ACETYLENIC CYANOENONES AS THERAPEUTICS FOR INFLAMMATION AND CARCINOGENESIS | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) | 2018-05-17 | — | — | US | disclosed |
| US-20180134654-A1 | ACETYLENIC CYANOENONES AS THERAPEUTICS FOR INFLAMMATION AND CARCINOGENESIS | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) | 2018-05-17 | — | — | US | disclosed |
| US-20180134654-A1 | ACETYLENIC CYANOENONES AS THERAPEUTICS FOR INFLAMMATION AND CARCINOGENESIS | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) | 2018-05-17 | — | — | US | disclosed |
| CN-100545140-C | High-purity (fluoroalkyl) benzene derivative and preparation method thereof | MITSUBISHI GAS CHEMICAL CO (JP) | 2009-09-30 | — | — | CN | disclosed |
| US-7405331-B2 | High-purity (fluoroalkyl)benzene derivative and process for producing the same | MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) | 2008-07-29 | — | — | US | disclosed |
| US-20060167324-A1 | High-purity (fluoroalkyl)benzene derivative and process for producing the same | MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) | 2006-07-27 | — | — | US | disclosed |
| CN-1653029-A | High-purity (fluoroalkyl) benzene derivative and preparation method thereof | MITSUBISHI GAS CHEMICAL CO (JP) | 2005-08-10 | — | — | CN | disclosed |
| EP-1500641-A1 | HIGH-PURITY (FLUOROALKYL)BENZENE DERIVATIVE AND PROCESS FOR PRODUCING THE SAME | MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) | 2005-01-26 | — | — | EP | disclosed |
| EP-0360324-B1 | TRICYCLIC AROMATASE INHIBITORS | AKZO N.V. (NL) | 1992-11-11 | — | — | EP | disclosed |
| US-5019585-A | Tricyclic aromatase inhibitors | AKZO N.V. (NL) | 1991-05-28 | — | — | US | disclosed |
| EP-0360324-A1 | Tricyclic aromatase inhibitors | AKZO N.V. (NL) | 1990-03-28 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180134654-A1 | ACETYLENIC CYANOENONES AS THERAPEUTICS FOR INFLAMMATION AND CARCINOGENESIS | ACOX3, ACOT7, ACOX1 | MEN1 3215/4885KMT2A 2593/4885KDM1A 2909/4885 |
| US-20060167324-A1 | High-purity (fluoroalkyl)benzene derivative and process for producing the same | HBB, AFF4, AFF2 | MEN1 4285/4885KMT2A 1619/4885KDM1A 2443/4885 |
| US-10233146-B2 | Acetylenic cyanoenones as therapeutics for inflammation and carcinogenesis | ACOX3, ACOT7, ACOX1 | MEN1 3187/4885KMT2A 2612/4885KDM1A 2917/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.