Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 1.00 |
| ▸ | MEN1 | O00255 | 3/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 3/20 | 1.00 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 1.00 |
| ▸ | PKM | P14618 | 1/20 | 1.00 |
| ▸ | HTR6 | P50406 | 10/20 | 0.75 |
| ▸ | LMNA | P02545 | 2/20 | 0.75 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.75 |
| ▸ | HPGD | P15428 | 1/20 | 0.75 |
| ▸ | TSHR | P16473 | 1/20 | 0.75 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.51 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29558135 | 0.86 | HTR6 (1.00) | HTTMEN1KMT2AL3MBTL1PKM | |
| SCHEMBL429849 | 0.86 | HTR6 (1.00) | HTTMEN1KMT2AL3MBTL1PKM | |
| Hydrochloric Acid SCHEMBL28794299 | 0.84 | HTR6 (0.96) | HTTMEN1KMT2AL3MBTL1PKM | |
| SCHEMBL31663420 | 0.83 | HTR6 (0.81) | HTTMEN1KMT2AL3MBTL1PKM | |
| SCHEMBL29414854 | 0.83 | HTR6 (0.75) | HTTMEN1KMT2AL3MBTL1PKM | |
| SCHEMBL1673252 | 0.83 | HTR6 (0.75) | HTTMEN1KMT2AL3MBTL1PKM | |
| SCHEMBL3967709 | 0.83 | HTR6 (0.75) | HTTMEN1KMT2AL3MBTL1PKM | |
| SCHEMBL9587047 | 0.83 | HTR6 (0.75) | HTTMEN1KMT2AL3MBTL1PKM | |
| SCHEMBL9270506 | 0.83 | HTT (0.70) | HTTMEN1KMT2AL3MBTL1PKM | |
| SCHEMBL1203289 | 0.82 | HTR6 (0.73) | HTTMEN1KMT2AL3MBTL1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101544592-B | Process for preparation of N-arylsulfonyl-3-substituted indoles | SUVEN LIFE SCIENCES LTD | 2013-08-21 | — | — | CN | disclosed |
| US-20080090860-A1 | Retinoid x receptor modulators | GARDINIER KEVIN M | 2008-04-17 | — | — | US | disclosed |
| US-7348359-B2 | Retinoid X receptor modulators | ELI LILLY AND COMPANY (US) | 2008-03-25 | — | — | US | disclosed |
| EP-1373240-B1 | RETINOID X RECEPTOR MODULATORS | LILLY CO ELI (US) | 2005-06-15 | — | — | EP | disclosed |
| US-20040167160-A1 | Retinoid x receptor modulators | LIGAND PHARMACEUTICALS INCORPORATED | 2004-08-26 | — | — | US | disclosed |
| EP-1373240-A2 | RETINOID X RECEPTOR MODULATORS | ELI LILLY AND COMPANY (US) | 2004-01-02 | — | — | EP | disclosed |
| WO-2002071827-A2 | RETINOID X RECEPTOR MODULATORS | ELI LILLY AND COMPANY (US) | 2002-09-19 | — | — | WO | disclosed |
| EP-0667350-B1 | Water-soluble phosphine-derivatives | HOFFMANN LA ROCHE (CH) | 1999-09-01 | — | — | EP | disclosed |
| US-5536858-A | CATALYSTS FOR HYDROGENATION USING PHOSPHINEARYLSULFONATES | HOFFMANN-LA ROCHE INC. (US) | 1996-07-16 | — | — | US | disclosed |
| EP-0667350-A1 | Water-soluble phosphine-derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1995-08-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040167160-A1 | Retinoid x receptor modulators | RXRA, RXRG, RXRB | HTT 3480/4885MEN1 4117/4885KMT2A 4050/4885 |
| US-20080090860-A1 | Retinoid x receptor modulators | RXRA, RXRG, RXRB | HTT 3569/4885MEN1 4261/4885KMT2A 4112/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.