Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.44 |
| ▸ | TSHR | P16473 | 7/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | PDE5A | O76074 | 1/20 | 0.44 |
| ▸ | REN | P00797 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.44 |
| ▸ | MAPT | P10636 | 10/20 | 0.43 |
| ▸ | MEN1 | O00255 | 7/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 7/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 5/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | PKM | P14618 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4865901 | 0.82 | KCNH2 (0.49) | MAPK1 | |
| SCHEMBL4862922 | 0.82 | KCNH2 (0.39) | USP2KMT2ASMN1; SMN2 | |
| SCHEMBL4868742 | 0.75 | NPSR1 (0.43) | HPGDALDH1A1KDM4EPOLBUSP2 | |
| SCHEMBL4862946 | 0.72 | BPTF (0.32) | HPGDALDH1A1KDM4EPOLBMAPK1 | |
| SCHEMBL3388141 | 0.67 | ALDH1A1 (0.57) | HPGDALDH1A1KDM4ETSHRPOLB | |
| SCHEMBL4865898 | 0.67 | PTGS2 (0.33) | HPGDALDH1A1KDM4EPOLBMAPK1 | |
| SCHEMBL3387083 | 0.66 | ESR1 (0.55) | ALDH1A1KDM4EPOLBPDE5AREN | |
| SCHEMBL20119638 | 0.65 | SMN1; SMN2 (0.53) | HPGDALDH1A1KDM4ETSHRPOLB | |
| SCHEMBL3385359 | 0.65 | LMNA (0.52) | HPGDALDH1A1KDM4ETSHRPOLB | |
| SCHEMBL3382545 | 0.65 | ESR1 (0.71) | HPGDALDH1A1KDM4EPOLBPDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7456187-B2 | Furanopyrimidine compounds as potassium ion channel inhibitors | XENTION LIMITED (GB) | 2008-11-25 | — | — | US | disclosed |
| CN-1964978-A | Furanopyrimidine compounds effective as potassium channel inhibitors | XENTION LTD (GB) | 2007-05-16 | — | — | CN | disclosed |
| EP-1758909-A1 | FURANOPYRIMIDINE COMPOUNDS EFFECTIVE AS POTASSIUM CHANNEL INHIBITORS | Xention Limited (GB) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005121149-A1 | FURANOPYRIMIDINE COMPOUNDS EFFECTIVE AS POTASSIUM CHANNEL INHIBITORS | XENTION DISCOVERY LIMITED (GB) | 2005-12-22 | — | — | WO | disclosed |
| US-20050282829-A1 | Furanopyrimidine compounds as potassium ion channel inhibitors | XENTION DISCOVERY LTD. (GB) | 2005-12-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050282829-A1 | Furanopyrimidine compounds as potassium ion channel inhibitors | KCNH3, HCN4, KCNH2 | HPGD 2400/4885ALDH1A1 3825/4885KDM4E 868/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.