Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.42 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.42 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | LTA4H | P09960 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12079909 | 0.77 | SIGMAR1 (0.53) | HTR1AADRA1AADRA1DADRA1BSIGMAR1 | |
| SCHEMBL17875123 | 0.75 | SIGMAR1 (0.53) | HTR1AADRA1AADRA1DADRA1BSIGMAR1 | |
| SCHEMBL486331 | 0.74 | SIGMAR1 (0.50) | HTR1AADRA1AADRA1DADRA1BSIGMAR1 | |
| SCHEMBL486366 | 0.74 | ALDH1A1 (0.42) | HTR1AADRA1AADRA1DADRA1BALDH1A1 | |
| SCHEMBL12078569 | 0.71 | SIGMAR1 (0.46) | HTR1AADRA1AADRA1DADRA1BSIGMAR1 | |
| SCHEMBL12080250 | 0.71 | SIGMAR1 (0.58) | HTR1AADRA1AADRA1DADRA1BSIGMAR1 | |
| SCHEMBL16585014 | 0.68 | TSHR (0.47) | MAPTALDH1A1HTTKDM4ELMNA | |
| SCHEMBL2767847 | 0.63 | RAB9A (0.56) | MAPTALDH1A1HTTKDM4EPOLB | |
| SCHEMBL4704046 | 0.62 | LTA4H (0.53) | HTR1AALDH1A1SIGMAR1KDM4ETMEM97 | |
| SCHEMBL2329109 | 0.62 | ALDH1A1 (0.67) | MAPTALDH1A1HTTKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2410854-B1 | SUBSTITUTED 1, 4-DIOXA-8-AZASPIRO Ý4,5¨DECANES USEFUL AS FUNGICIDES AND A PROCESS FOR THE PREPARATION THEREOF | COUNCIL SCIENT IND RES (IN) | 2016-06-29 | — | — | EP | claimed |
| US-8841296-B2 | Substituted 1, 4-dioxa-8-azaspiro[4,5]decanes useful as fungicides and a process for the preparation thereof | Council of Scientific and Industrial Research, Anusandhan Bhawan, Rafi Marg (IN) | 2014-09-23 | — | — | US | claimed |
| US-20120225877-A1 | SUBSTITUTED 1, 4-DIOXA-8-AZASPIRO[4,5]DECANES USEFUL AS FUNGICIDES AND A PROCESS FOR THE PREPARATION THEREOF | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH; ANUSANDHAN BHAWAN, RAFI MARG. (IN) | 2012-09-06 | — | — | US | claimed |
| EP-2410854-B1 | SUBSTITUTED 1, 4-DIOXA-8-AZASPIRO Ý4,5¨DECANES USEFUL AS FUNGICIDES AND A PROCESS FOR THE PREPARATION THEREOF | COUNCIL SCIENT IND RES (IN) | 2016-06-29 | — | — | EP | disclosed |
| EP-2410854-B1 | SUBSTITUTED 1, 4-DIOXA-8-AZASPIRO Ý4,5¨DECANES USEFUL AS FUNGICIDES AND A PROCESS FOR THE PREPARATION THEREOF | COUNCIL SCIENT IND RES (IN) | 2016-06-29 | — | — | EP | disclosed |
| US-8841296-B2 | Substituted 1, 4-dioxa-8-azaspiro[4,5]decanes useful as fungicides and a process for the preparation thereof | Council of Scientific and Industrial Research, Anusandhan Bhawan, Rafi Marg (IN) | 2014-09-23 | — | — | US | disclosed |
| US-8841296-B2 | Substituted 1, 4-dioxa-8-azaspiro[4,5]decanes useful as fungicides and a process for the preparation thereof | Council of Scientific and Industrial Research, Anusandhan Bhawan, Rafi Marg (IN) | 2014-09-23 | — | — | US | disclosed |
| US-8841296-B2 | Substituted 1, 4-dioxa-8-azaspiro[4,5]decanes useful as fungicides and a process for the preparation thereof | Council of Scientific and Industrial Research, Anusandhan Bhawan, Rafi Marg (IN) | 2014-09-23 | — | — | US | disclosed |
| US-20120225877-A1 | SUBSTITUTED 1, 4-DIOXA-8-AZASPIRO[4,5]DECANES USEFUL AS FUNGICIDES AND A PROCESS FOR THE PREPARATION THEREOF | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH; ANUSANDHAN BHAWAN, RAFI MARG. (IN) | 2012-09-06 | — | — | US | disclosed |
| US-20120225877-A1 | SUBSTITUTED 1, 4-DIOXA-8-AZASPIRO[4,5]DECANES USEFUL AS FUNGICIDES AND A PROCESS FOR THE PREPARATION THEREOF | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH; ANUSANDHAN BHAWAN, RAFI MARG. (IN) | 2012-09-06 | — | — | US | disclosed |
| US-20120225877-A1 | SUBSTITUTED 1, 4-DIOXA-8-AZASPIRO[4,5]DECANES USEFUL AS FUNGICIDES AND A PROCESS FOR THE PREPARATION THEREOF | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH; ANUSANDHAN BHAWAN, RAFI MARG. (IN) | 2012-09-06 | — | — | US | disclosed |
| EP-2410854-A2 | SUBSTITUTED 1, 4-DIOXA-8-AZASPIRO Ý4,5¨DECANES USEFUL AS FUNGICIDES AND A PROCESS FOR THE PREPARATION THEREOF | Council of Scientific & Industrial Research (IN) | 2012-02-01 | — | — | EP | disclosed |
| WO-2010109299-A2 | SUBSTITUTED 1, 4-DIOXA-8-AZASPIRO [4,5] DECANES USEFUL AS FUNGICIDES AND A PROCESS FOR THE PREPARATION THEREOF | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2010-09-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120225877-A1 | SUBSTITUTED 1, 4-DIOXA-8-AZASPIRO[4,5]DECANES USEFUL AS FUNGICIDES AND A PROCESS FOR THE PREPARATION THEREOF | CYP4X1, CYP51A1, CYP1A1 | HTR1A 1022/4885ADRA1A 683/4885ADRA1D 1224/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.