Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 7/20 | 0.60 |
| ▸ | HTR1B | P28222 | 5/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | DRD4 | P21917 | 2/20 | 0.53 |
| ▸ | DRD3 | P35462 | 2/20 | 0.53 |
| ▸ | DRD2 | P14416 | 1/20 | 0.53 |
| ▸ | HTR7 | P34969 | 3/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.48 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.48 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10736779 | 0.85 | HTR1B (0.49) | HTR1AHTR1BMEN1MAPK1KMT2A | |
| SCHEMBL10735471 | 0.85 | DRD2 (0.50) | HTR1AHTR1BDRD4DRD3DRD2 | |
| SCHEMBL10736784 | 0.85 | HTR1B (0.49) | HTR1AHTR1BMEN1MAPK1KMT2A | |
| SCHEMBL10567823 | 0.83 | HTR1A (0.50) | HTR1AHTR1BDRD4DRD2HTR2C | |
| SCHEMBL3799623 | 0.82 | HTR1B (0.64) | HTR1AHTR1BMEN1MAPK1KMT2A | |
| SCHEMBL3798923 | 0.81 | HTR1B (0.62) | HTR1AHTR1BMEN1MAPK1KMT2A | |
| SCHEMBL2986267 | 0.80 | RET (0.45) | HTR1AHTR1BDRD4DRD3DRD2 | |
| SCHEMBL3555909 | 0.79 | HTR1B (0.55) | HTR1AHTR1BMEN1KMT2ADRD4 | |
| SCHEMBL1545429 | 0.79 | HTR1B (0.60) | HTR1AHTR1BMEN1MAPK1KMT2A | |
| SCHEMBL4073823 | 0.79 | HTR1B (0.60) | HTR1AHTR1BMEN1MAPK1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9650664-B2 | Use of photocleavable compounds | FEMTONICS KFT (HU) | 2017-05-16 | — | — | US | disclosed |
| US-20140234883-A1 | USE OF PHOTOCLEAVABLE COMPOUNDS | FEMTONICS KFT (HU) | 2014-08-21 | — | — | US | disclosed |
| US-20080139547-A1 | ACETYLENE DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE | PHARMACYCLICS, INC. (US) | 2008-06-12 | — | — | US | disclosed |
| US-7368572-B2 | Acetylene derivatives as inhibitors of histone deacetylase | PHARMACYCLICS, INC. (US) | 2008-05-06 | — | — | US | disclosed |
| EP-1656348-B1 | ACETYLENE DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE | AXYS PHARM INC (US) | 2007-02-07 | — | — | EP | disclosed |
| EP-1656348-A1 | ACETYLENE DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE | AXYS PHARMACEUTICALS, INC. (US) | 2006-05-17 | — | — | EP | disclosed |
| US-20050131018-A1 | Acetylene derivatives as inhibitors of histone deacetylase | AXYS PHARMACEUTICALS, INC. (US) | 2005-06-16 | — | — | US | disclosed |
| EP-1513809-A1 | 1-SULFONYL-4-AMINOALKOXY INDOLE DERIVATIVES AS 5-HT6-RECEPTOR MODULATORS FOR THE TREATMENT OF CNS-DISORDERS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-03-16 | — | — | EP | disclosed |
| WO-2005019174-A1 | ACETYLENE DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE | AXYS PHARMACEUTICALS, INC. (US) | 2005-03-03 | — | — | WO | disclosed |
| US-6774241-B2 | HT3 RECEPTOR ANTAGONISTS FOR NERVOUS SYSTEM, PSYCHOLOGICAL, EATING, AND SLEEP DISORDER TREATMENT | ROCHE PALO ALTO LLC | 2004-08-10 | — | — | US | disclosed |
| WO-2003104193-A1 | 1-SULFONYL-4-AMINOALKOXY INDOLE DERIVATIVES AS 5-HT6-RECEPTOR MODULATORS FOR THE TREATMENT OF CNS-DISORDERS | F. HOFFMANN-LA ROCHE AG (CH) | 2003-12-18 | — | — | WO | disclosed |
| US-20030229069-A1 | 1-Sulfonyl-4-aminoalkoxy indole derivatives and uses thereof | ROCHE PALO ALTO LLC | 2003-12-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080139547-A1 | ACETYLENE DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE | HDAC1, HDAC10, HDAC2 | HTR1A 2805/4885HTR1B 3303/4885MEN1 3063/4885 |
| US-20050131018-A1 | Acetylene derivatives as inhibitors of histone deacetylase | HDAC1, HDAC10, HDAC2 | HTR1A 2805/4885HTR1B 3303/4885MEN1 3063/4885 |
| US-20030229069-A1 | 1-Sulfonyl-4-aminoalkoxy indole derivatives and uses thereof | IDO1, TPH1, SLC6A4 | HTR1A 13/4885HTR1B 11/4885MEN1 1398/4885 |
| US-20140234883-A1 | USE OF PHOTOCLEAVABLE COMPOUNDS | ERCC1, ERCC4, ERCC5 | HTR1A 3269/4885HTR1B 2879/4885MEN1 782/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.