Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 1/20 | 0.45 |
| ▸ | HTR7 | P34969 | 2/20 | 0.44 |
| ▸ | HTR1B | P28222 | 2/20 | 0.44 |
| ▸ | HTR1A | P08908 | 4/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | SRC | P12931 | 1/20 | 0.40 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2975469 | 0.86 | RET (0.47) | RETHTR1BHTR1AJAK2JAK3 | |
| SCHEMBL2982161 | 0.83 | RET (0.54) | RETHTR1BJAK2JAK3MAPK14 | |
| SCHEMBL17255752 | 0.81 | TSHR (0.51) | RETHTR1BHTR1AALDH1A1DRD2 | |
| SCHEMBL2980622 | 0.81 | NR4A2 (0.46) | HTR7HTR1BJAK2ALDH1A1PRKCQ | |
| SCHEMBL4864576 | 0.80 | HTR1A (0.60) | HTR7HTR1BHTR1AALDH1A1DRD2 | |
| SCHEMBL17255754 | 0.77 | SRC (0.46) | RETHTR1BHTR1AJAK2JAK3 | |
| SCHEMBL9132797 | 0.77 | RXFP1 (0.58) | ALDH1A1NR4A2 | |
| SCHEMBL9130935 | 0.73 | NR4A2 (0.53) | HTR1ANR4A2 | |
| SCHEMBL10736779 | 0.72 | HTR1B (0.49) | HTR7HTR1BHTR1ADRD2DRD4 | |
| SCHEMBL10736784 | 0.72 | HTR1B (0.49) | HTR7HTR1BHTR1ADRD2DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7781591-B2 | Substituted 3-cyanopyridines as protein kinase inhibitors | WYETH LLC (US) | 2010-08-24 | — | — | US | claimed |