Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.38 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | MLYCD | O95822 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4874740 | 0.88 | ALDH1A1 (0.45) | SMN1; SMN2ALDH1A1GLATSHRTP53 | |
| SCHEMBL4874004 | 0.86 | ALDH1A1 (0.42) | SMN1; SMN2ALDH1A1GLATSHRTP53 | |
| SCHEMBL8516064 | 0.82 | ALDH1A1 (0.59) | SMN1; SMN2ALDH1A1GLATSHRTP53 | |
| SCHEMBL5461474 | 0.76 | NPC1 (0.61) | SMN1; SMN2ALDH1A1GLAMEN1KMT2A | |
| SCHEMBL10752510 | 0.74 | SMN1; SMN2 (0.69) | SMN1; SMN2ALDH1A1GLATSHRTP53 | |
| SCHEMBL8303367 | 0.74 | HTT (0.52) | SMN1; SMN2ALDH1A1MEN1KMT2AOPRM1 | |
| SCHEMBL3583408 | 0.74 | TP53 (0.43) | SMN1; SMN2ALDH1A1GLATSHRTP53 | |
| SCHEMBL325730 | 0.74 | TSHR (0.53) | SMN1; SMN2ALDH1A1GLATSHRTP53 | |
| SCHEMBL307080 | 0.72 | KMT2A (0.50) | ALDH1A1MEN1KMT2ACYP3A4CYP2C9 | |
| SCHEMBL7238334 | 0.71 | KDM4E (0.41) | ALDH1A1GLATSHRTP53MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7442693-B2 | Diazepine compounds as ligands of the melanocortin 1 and/or 4 receptors | SMITHKLINE BEECHAM CORPORATION (US) | 2008-10-28 | — | — | US | disclosed |
| US-20070270411-A1 | Novel Diazepine Compounds as Ligands of the Melanocortin 1 and/or 4 Receptors | SMITHKLINE BEECHAM CORPORATION | 2007-11-22 | — | — | US | disclosed |
| WO-2005118573-A1 | NOVEL DIAZEPINE COMPOUNDS AS LIGANDS OF THE MELANOCORTIN 1 AND/OR 4 RECEPTORS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-12-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070270411-A1 | Novel Diazepine Compounds as Ligands of the Melanocortin 1 and/or 4 Receptors | MC4R, MC3R, MC5R | SMN1; SMN2 3702/4885ALDH1A1 2986/4885GLA 4736/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.