Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4865282 | 0.88 | SMN1; SMN2 (0.43) | ALDH1A1GLATSHRTP53SMN1; SMN2 | |
| SCHEMBL4874004 | 0.88 | ALDH1A1 (0.42) | ALDH1A1GLATSHRTP53SMN1; SMN2 | |
| SCHEMBL308738 | 0.79 | ALDH1A1 (0.66) | ALDH1A1GLATSHRTP53SMN1; SMN2 | |
| SCHEMBL8303367 | 0.76 | HTT (0.52) | ALDH1A1SMN1; SMN2MEN1KMT2AOPRM1 | |
| SCHEMBL3583408 | 0.76 | TP53 (0.43) | ALDH1A1GLATSHRTP53SMN1; SMN2 | |
| SCHEMBL11063095 | 0.73 | ALDH1A1 (0.44) | ALDH1A1SMN1; SMN2KMT2AOPRM1NPC1 | |
| SCHEMBL7238334 | 0.73 | KDM4E (0.41) | ALDH1A1GLATSHRTP53MEN1 | |
| SCHEMBL11065640 | 0.72 | ALDH1A1 (0.43) | ALDH1A1TP53NPC1RAB9ACYP3A4 | |
| SCHEMBL11062234 | 0.72 | ALDH1A1 (0.43) | ALDH1A1OPRM1NPC1RAB9AHPGD | |
| SCHEMBL11065506 | 0.72 | L3MBTL1 (0.50) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7442693-B2 | Diazepine compounds as ligands of the melanocortin 1 and/or 4 receptors | SMITHKLINE BEECHAM CORPORATION (US) | 2008-10-28 | — | — | US | disclosed |
| US-20070270411-A1 | Novel Diazepine Compounds as Ligands of the Melanocortin 1 and/or 4 Receptors | SMITHKLINE BEECHAM CORPORATION | 2007-11-22 | — | — | US | disclosed |
| WO-2005118573-A1 | NOVEL DIAZEPINE COMPOUNDS AS LIGANDS OF THE MELANOCORTIN 1 AND/OR 4 RECEPTORS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-12-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070270411-A1 | Novel Diazepine Compounds as Ligands of the Melanocortin 1 and/or 4 Receptors | MC4R, MC3R, MC5R | ALDH1A1 2986/4885GLA 4736/4885TSHR 203/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.