Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | CNR2 | P34972 | 2/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CCR5 | P51681 | 2/20 | 0.42 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MITF | O75030 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7141111 | 0.82 | HTT (0.63) | HTTACHECNR2CNR1ATM | |
| SCHEMBL4874740 | 0.76 | ALDH1A1 (0.45) | SMN1; SMN2MEN1NPC1ALDH1A1RAB9A | |
| SCHEMBL157266 | 0.76 | HTT (0.63) | HTTACHECNR2CNR1ATM | |
| SCHEMBL8303697 | 0.75 | HTT (0.61) | HTTACHECNR2CNR1ATM | |
| SCHEMBL2724136 | 0.75 | HTT (0.71) | HTTACHECNR2CNR1ATM | |
| SCHEMBL3482861 | 0.74 | HTT (0.65) | HTTACHECNR2CNR1SMN1; SMN2 | |
| SCHEMBL4865282 | 0.74 | SMN1; SMN2 (0.43) | SMN1; SMN2MEN1NPC1ALDH1A1RAB9A | |
| SCHEMBL4874004 | 0.74 | ALDH1A1 (0.42) | SMN1; SMN2MEN1NPC1ALDH1A1RAB9A | |
| SCHEMBL20218939 | 0.72 | CNR2 (0.75) | HTTACHECNR2CNR1ATM | |
| SCHEMBL5859331 | 0.71 | KDM4E (0.43) | SMN1; SMN2LMNAKDM4EMEN1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0898569-A1 | PIPERIDINES AND PYRROLIDINES | MERCK PATENT GmbH (DE) | 1999-03-03 | — | — | EP | disclosed |
| WO-1997040038-A1 | PIPERIDINES AND PYRROLIDINES | MERCK PATENT GMBH (DE) | 1997-10-30 | — | — | WO | disclosed |