SCHEMBL8516064

SCHEMBL8516064

CCN(C(=O)CC(=O)OC)c1ccccc1

nearest known ligand 0.66

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.59
TSHR P16473 2/20 0.59
GLA P06280 1/20 0.59
MEN1 O00255 2/20 0.54
KMT2A Q03164 2/20 0.54
SMN1; SMN2 Q16637 3/20 0.50
TP53 P04637 2/20 0.49
POLB P06746 1/20 0.47
MAPT P10636 1/20 0.47
HPGD P15428 2/20 0.47
HTT P42858 1/20 0.44
KDM4E B2RXH2 1/20 0.44
TDP1 Q9NUW8 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1032203 0.88 SMN1; SMN2 (0.60) ALDH1A1TSHRGLAMEN1KMT2A
SCHEMBL308738 0.84 ALDH1A1 (0.66) ALDH1A1TSHRGLAMEN1KMT2A
SCHEMBL5461474 0.83 NPC1 (0.61) ALDH1A1GLAMEN1KMT2ASMN1; SMN2
SCHEMBL10622511 0.82 ALDH1A1 (0.63) ALDH1A1TSHRGLAMEN1KMT2A
SCHEMBL10752510 0.82 SMN1; SMN2 (0.69) ALDH1A1TSHRGLAMEN1KMT2A
SCHEMBL4865282 0.82 SMN1; SMN2 (0.43) ALDH1A1TSHRGLAMEN1KMT2A
SCHEMBL325730 0.81 TSHR (0.53) ALDH1A1TSHRGLAMEN1KMT2A
SCHEMBL341786 0.81 ALDH1A1 (0.61) ALDH1A1TSHRGLAMEN1KMT2A
SCHEMBL6657920 0.81 ALDH1A1 (0.61) ALDH1A1TSHRGLAMEN1KMT2A
SCHEMBL7653262 0.80 ALDH1A1 (0.66) ALDH1A1TSHRGLAMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1957498-B1 INHIBITORS OF VEGF RECEPTOR AND HGF RECEPTOR SIGNALING METHYLGENE INC (CA) 2017-02-15 EP disclosed
US-9102592-B2 Intermediate compounds and processes for the preparation of quinoline derivatives such as laquinimod sodium MAPI PHARMA LTD. (IL) 2015-08-11 US disclosed
US-9102592-B2 Intermediate compounds and processes for the preparation of quinoline derivatives such as laquinimod sodium MAPI PHARMA LTD. (IL) 2015-08-11 US disclosed
US-20150051419-A1 INTERMEDIATE COMPOUNDS AND PROCESSES FOR THE PREPARATION OF QUINOLINE DERIVATIVES SUCH AS LAQUINIMOD SODIUM MAPI PHARMA LTD. (IL) 2015-02-19 US disclosed
US-20150051419-A1 INTERMEDIATE COMPOUNDS AND PROCESSES FOR THE PREPARATION OF QUINOLINE DERIVATIVES SUCH AS LAQUINIMOD SODIUM MAPI PHARMA LTD. (IL) 2015-02-19 US disclosed
US-8865742-B2 Intermediate compounds and processes for the preparation of quinoline derivatives such as Laquinimod sodium MAPI PHARMA LTD. (IL) 2014-10-21 US disclosed
US-8865742-B2 Intermediate compounds and processes for the preparation of quinoline derivatives such as Laquinimod sodium MAPI PHARMA LTD. (IL) 2014-10-21 US disclosed
EP-2642855-A1 INTERMEDIATE COMPOUNDS AND PROCESSES FOR THE PREPARATION OF QUINOLINE DERIVATIVES SUCH AS LAQUINIMOD SODIUM Mapi Pharma Limited (IL) 2013-10-02 EP disclosed
US-20130245065-A1 INTERMEDIATE COMPOUNDS AND PROCESSES FOR THE PREPARATION OF QUINOLINE DERIVATIVES SUCH AS LAQUINIMOD SODIUM MAPI PHARMA LTD. (IL) 2013-09-19 US disclosed
US-20130245065-A1 INTERMEDIATE COMPOUNDS AND PROCESSES FOR THE PREPARATION OF QUINOLINE DERIVATIVES SUCH AS LAQUINIMOD SODIUM MAPI PHARMA LTD. (IL) 2013-09-19 US disclosed
US-8329726-B2 Inhibitors of VEGF receptor and HGF receptor signaling METHYLGENE INC. (CA) 2012-12-11 US disclosed
WO-2012070051-A1 INTERMEDIATE COMPOUNDS AND PROCESSES FOR THE PREPARATION OF QUINOLINE DERIVATIVES SUCH AS LAQUINIMOD SODIUM MAPI PHARMA LTD. (IL) 2012-05-31 WO disclosed
WO-2012070051-A1 INTERMEDIATE COMPOUNDS AND PROCESSES FOR THE PREPARATION OF QUINOLINE DERIVATIVES SUCH AS LAQUINIMOD SODIUM MAPI PHARMA LTD. (IL) 2012-05-31 WO disclosed
US-20120083482-A1 INHIBITORS OF VEGF RECEPTOR AND HGF RECEPTOR SIGNALING METHYLGENE INC. 2012-04-05 US disclosed
US-20120083482-A1 INHIBITORS OF VEGF RECEPTOR AND HGF RECEPTOR SIGNALING METHYLGENE INC. 2012-04-05 US disclosed
US-8093264-B2 Fused heterocycles as inhibitors of VEGF receptor and HGF receptor signaling METHYLGENE INC. (CA) 2012-01-10 US disclosed
US-8093264-B2 Fused heterocycles as inhibitors of VEGF receptor and HGF receptor signaling METHYLGENE INC. (CA) 2012-01-10 US disclosed
WO-2008041053-A2 INHIBITORS OF VEGF RECEPTOR AND HGF RECEPTOR SIGNALING METHYLGENE, INC. (CA) 2008-04-10 WO disclosed
US-20070004675-A1 Inhibitors of VEGF receptor and HGF receptor signaling METHYLGENE, INC. 2007-01-04 US disclosed
US-20070004675-A1 Inhibitors of VEGF receptor and HGF receptor signaling METHYLGENE, INC. 2007-01-04 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150051419-A1 INTERMEDIATE COMPOUNDS AND PROCESSES FOR THE PREPARATION OF QUINOLINE DERIVATIVES SUCH AS LAQUINIMOD SODIUM TLR7, NQO1, NQO2 ALDH1A1 246/4885TSHR 4706/4885GLA 2702/4885
US-20070004675-A1 Inhibitors of VEGF receptor and HGF receptor signaling HGF, MET, FLT1 ALDH1A1 1649/4885TSHR 396/4885GLA 2918/4885
US-20120083482-A1 INHIBITORS OF VEGF RECEPTOR AND HGF RECEPTOR SIGNALING HGF, MET, KDR ALDH1A1 411/4885TSHR 173/4885GLA 3297/4885
US-20130245065-A1 INTERMEDIATE COMPOUNDS AND PROCESSES FOR THE PREPARATION OF QUINOLINE DERIVATIVES SUCH AS LAQUINIMOD SODIUM TLR7, NQO1, NQO2 ALDH1A1 246/4885TSHR 4706/4885GLA 2702/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.