SCHEMBL486657

SCHEMBL486657

NNc1cc(Cl)cc(Cl)c1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
IDO1 P14902 4/20 0.50
TSHR P16473 1/20 0.50
CYP3A4 P08684 2/20 0.45
TP53 P04637 1/20 0.45
MAPT P10636 4/20 0.44
ALDH1A1 P00352 3/20 0.44
LMNA P02545 2/20 0.44
GAA P10253 1/20 0.44
ALOX12 P18054 1/20 0.44
DEPTOR Q8TB45 1/20 0.41
RAPGEF4 Q8WZA2 1/20 0.39
CYP1A2 P05177 2/20 0.38
CYP2C9 P11712 2/20 0.38
CYP2C19 P33261 2/20 0.38
HPGD P15428 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
RAB9A P51151 2/20 0.37
MEN1 O00255 1/20 0.37
KMT2A Q03164 1/20 0.37
NPSR1 Q6W5P4 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Water SCHEMBL29052961 0.97 IDO1 (0.48) IDO1TSHRCYP3A4TP53MAPT
Hydrochloric Acid SCHEMBL379523 0.97 IDO1 (0.48) IDO1TSHRCYP3A4TP53MAPT
SCHEMBL18706950 0.82 IDO1 (0.38) IDO1TSHRCYP3A4TP53MAPT
SCHEMBL11942143 0.82 IDO1 (0.42) IDO1TSHRCYP3A4MAPTALDH1A1
SCHEMBL360242 0.82 RAPGEF4 (0.48) IDO1ALDH1A1RAPGEF4CYP1A2CYP2C9
Hydrochloric Acid SCHEMBL7413150 0.80 RAPGEF4 (0.45) IDO1MAPTALDH1A1LMNAGAA
Hydrochloric Acid SCHEMBL670927 0.80 RAPGEF4 (0.47) IDO1ALDH1A1RAPGEF4CYP1A2CYP2C9
SCHEMBL11679341 0.77 MEN1 (0.36) IDO1CYP3A4MAPTALDH1A1LMNA
SCHEMBL4374429 0.77 RAPGEF4 (0.53) IDO1CYP3A4MAPTALDH1A1RAPGEF4
SCHEMBL27123131 0.77 ALDH1A1 (0.40) IDO1TP53MAPTALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 147 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1177165-B1 PROCESSES FOR PREPARING PESTICIDAL INTERMEDIATES BAYER CROPSCIENCE SA (FR) 2004-07-14 EP claimed
EP-0918052-B1 Improved polymeric mdi color BAYER AG (US) 2003-05-28 EP claimed
US-20260008783-A1 MODULATORS OF FSHR AND USES THEREOF GEDEON RICHTER PLC (HU) 2026-01-08 US disclosed
EP-4577206-A2 NOVEL MODULATORS OF FSHR AND USES THEREOF Celmatix Inc. (US) 2025-07-02 EP disclosed
WO-2024263803-A2 NOVEL MODULATORS OF FSHR AND USES THEREOF CELMATIX INC. (US) 2024-12-26 WO disclosed
WO-2024044778-A2 NOVEL MODULATORS OF FSHR AND USES THEREOF CELMATIX INC. (US) 2024-02-29 WO disclosed
WO-2024044778-A2 NOVEL MODULATORS OF FSHR AND USES THEREOF CELMATIX INC. (US) 2024-02-29 WO disclosed
EP-3675847-B1 SPIROCYCLE COMPOUNDS AND METHODS OF MAKING AND USING SAME H LUNDBECK AS (DK) 2023-07-12 EP disclosed
CN-116396291-A Application of 1-amide and 1-hydrazide substituted beta-carboline derivative as agricultural bactericide 南京农业大学 2023-07-07 CN disclosed
CN-113754649-B Indole derivative containing oxadiazole, triazole and pyrazole structural units and application thereof 贵州大学 2023-04-18 CN disclosed
CN-109863140-B 3-oxo-2, 6-diphenyl-2, 3-dihydropyridazine-4-carboxamide 拜耳医药股份有限公司 2023-02-21 CN disclosed
EP-0244075-A1 Gametocidal pyrazoles ELI LILLY AND COMPANY (US) 1987-11-04 EP disclosed
US-4539579-A ELECTROCHROMIC RECORDING THE HILTON-DAVIS CHEMICAL CO. (US) 1985-09-03 US disclosed
EP-0141962-A1 Hydrazine derivatives of fluorans and use thereof in electrochromic recording systems THE HILTON - DAVIS CHEMICAL COMPANY (US) 1985-05-22 EP disclosed
EP-0126970-A2 Anxiolytic and anti-depressant thienopyridine derivatives BEECHAM GROUP PLC (GB) 1984-12-05 EP disclosed
EP-0108382-A1 Hydrazine derivatives of phthalides and furopyridinones, methods for making and for using said compounds STERLING DRUG INC. (US) 1984-05-16 EP disclosed
US-4351948-A Imidazole hydrazone derivatives G.D. SEARLE & CO. (US) 1982-09-28 US disclosed
US-4293553-A ANTITHROMBOTIC AGENT Ishikawa, Masayuki (JP) 1981-10-06 US disclosed
US-4045169-A FLUORESCENT DYES HOECHST AKTIENGESELLSCHAFT (DT) 1977-08-30 US disclosed
US-3957815-A 3-[3',4'-Dichloro-6'-alkyl-phenyl]-Δ2 -pyrazoline derivatives and their use as optical brighteners HOECHST AKTIENGESELLSCHAFT (DT) 1976-05-18 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260008783-A1 MODULATORS OF FSHR AND USES THEREOF FSHR, GNRHR, LHCGR IDO1 3504/4885TSHR 16/4885CYP3A4 3359/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.