Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.73 |
| ▸ | POLB | P06746 | 2/20 | 0.69 |
| ▸ | HTT | P42858 | 2/20 | 0.66 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.63 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.63 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.63 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.63 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.63 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.63 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.63 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.63 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.63 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.63 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.63 |
| ▸ | LMNA | P02545 | 4/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.62 |
| ▸ | MEN1 | O00255 | 3/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.61 |
| ▸ | CASP3 | P42574 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1753903 | 0.89 | TDP1 (0.79) | TDP1POLBHTTHDAC6HDAC3 | |
| SCHEMBL9464627 | 0.87 | POLB (0.88) | TDP1POLBHTTHDAC6HDAC3 | |
| SCHEMBL11252751 | 0.87 | HTT (0.78) | TDP1POLBHTTHDAC6HDAC3 | |
| SCHEMBL28774204 | 0.84 | TDP1 (0.73) | TDP1POLBHTTHDAC6HDAC3 | |
| SCHEMBL8401892 | 0.84 | TDP1 (0.73) | TDP1POLBHTTHDAC6HDAC3 | |
| SCHEMBL4025035 | 0.84 | TDP1 (0.73) | TDP1POLBHTTHDAC6HDAC3 | |
| SCHEMBL5442495 | 0.84 | TDP1 (0.73) | TDP1POLBHTTHDAC6HDAC3 | |
| SCHEMBL9464308 | 0.84 | HTT (0.89) | TDP1POLBHTTHDAC6HDAC3 | |
| SCHEMBL31174344 | 0.84 | TDP1 (0.73) | TDP1POLBHTTHDAC6HDAC3 | |
| SCHEMBL4025039 | 0.84 | TDP1 (0.73) | TDP1POLBHTTHDAC6HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110423217-B | Preparation method of conjugated eneyne compound | 大连理工大学 | 2022-04-12 | — | — | CN | claimed |
| CN-108250141-B | Tyrosine methyl ester modified N- (8-quinolyl) acetamide compound, and synthesis method and application thereof | 华南师范大学 | 2021-04-20 | — | — | CN | claimed |
| CN-108358978-B | Enhanced magnetic targeting cell fluorescence nano probe and preparation method thereof | 四川农业大学 | 2020-09-08 | — | — | CN | claimed |
| CN-110423217-A | A kind of preparation method of conjugated enynes compound | UNIV DALIAN TECH | 2019-11-08 | — | — | CN | claimed |
| CN-107522658-B | Sour cyanines probe in a kind of symmetrical side in 1,3 based on amide groups quinoline and its preparation method and application | 常州大学 | 2019-06-04 | — | — | CN | claimed |
| CN-108358978-A | A kind of enhancement magnetic targeted cell fluorescence nano-probe and preparation method thereof | 四川农业大学 | 2018-08-03 | — | — | CN | claimed |
| CN-108250141-A | Methyl-P-tyrosine modifies N-（8- quinolyls）Acetamide compound, synthetic method and application | 华南师范大学 | 2018-07-06 | — | — | CN | claimed |
| CN-107522658-A | A kind of 1,3 symmetrical sour cyanines probes in side based on amide groups quinoline and its preparation method and application | 常州大学 | 2017-12-29 | — | — | CN | claimed |
| CN-105038769-B | Fluorescent probe based on 8-aminoquinoline derivative and synthetic method and application thereof | 渤海大学 | 2017-01-18 | — | — | CN | claimed |
| CN-104031634-B | A kind of ratio fluorescent nano probe and its preparation method and application | SUN YAT-SEN UNIVERSITY (CN) | 2015-11-11 | — | — | CN | claimed |
| CN-102898461-A | Method for preparing fluorescent and magnetic resonance dual-functional nanometer super-paramagnetic particles for detecting life system | NANJING UNIVERSITY OF TECHNOLOGY | 2013-01-30 | — | — | CN | claimed |
| CN-110423217-B | Preparation method of conjugated eneyne compound | 大连理工大学 | 2022-04-12 | — | — | CN | disclosed |
| CN-108250141-B | Tyrosine methyl ester modified N- (8-quinolyl) acetamide compound, and synthesis method and application thereof | 华南师范大学 | 2021-04-20 | — | — | CN | disclosed |
| CN-108358978-B | Enhanced magnetic targeting cell fluorescence nano probe and preparation method thereof | 四川农业大学 | 2020-09-08 | — | — | CN | disclosed |
| CN-108358978-B | Enhanced magnetic targeting cell fluorescence nano probe and preparation method thereof | 四川农业大学 | 2020-09-08 | — | — | CN | disclosed |
| EP-1806346-A1 | Substituted piperazine compounds and their use as fatty acid oxidation inhibitors | CV THERAPEUTICS, INC. (US) | 2007-07-11 | — | — | EP | disclosed |
| EP-1567525-B1 | SUBSTITUTED PIPERAZINE COMPOUNDS AND THEIR USE AS FATTY ACID OXIDATION INHIBITORS | CV THERAPEUTICS INC (US) | 2007-06-27 | — | — | EP | disclosed |
| US-20070004751-A1 | Substituted heterocyclic compounds | ELZEIN ELFATIH | 2007-01-04 | — | — | US | disclosed |
| US-7125876-B2 | Substituted heterocyclic compounds | CV THERAPEUTICS, INC. (US) | 2006-10-24 | — | — | US | disclosed |
| US-20040152890-A1 | Substituted heterocyclic compounds | CV THERAPEUTICS, INC. | 2004-08-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040152890-A1 | Substituted heterocyclic compounds | KCNH1, SDHA, COQ8A | TDP1 3448/4885POLB 2675/4885HTT 2557/4885 |
| US-20070004751-A1 | Substituted heterocyclic compounds | KCNH1, SDHA, COQ8A | TDP1 3484/4885POLB 2485/4885HTT 2259/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.