Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 1/20 | 0.53 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.53 |
| ▸ | FABP3 | P05413 | 1/20 | 0.47 |
| ▸ | FABP4 | P15090 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | HPGD | P15428 | 5/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.44 |
| ▸ | GRM1 | Q13255 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.44 |
| ▸ | SELL | P14151 | 2/20 | 0.42 |
| ▸ | SELP | P16109 | 2/20 | 0.42 |
| ▸ | CA12 | O43570 | 2/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | CA7 | P43166 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31335772 | 1.00 | GABRA1 (0.53) | GABRA1GABRB2FABP3FABP4ALDH1A1 | |
| SCHEMBL212716 | 0.82 | FABP3 (0.60) | GABRA1GABRB2FABP3FABP4ALDH1A1 | |
| SCHEMBL29593831 | 0.82 | FABP3 (0.60) | GABRA1GABRB2FABP3FABP4ALDH1A1 | |
| SCHEMBL15524641 | 0.82 | HDAC4 (0.42) | ALDH1A1HSD17B10KDM4EHPGDTDP1 | |
| SCHEMBL11797932 | 0.81 | FABP3 (0.58) | GABRA1GABRB2FABP3FABP4ALDH1A1 | |
| SCHEMBL10618114 | 0.81 | FABP3 (0.58) | GABRA1GABRB2FABP3FABP4ALDH1A1 | |
| SCHEMBL11794494 | 0.81 | FABP3 (0.58) | GABRA1GABRB2FABP3FABP4ALDH1A1 | |
| SCHEMBL11783529 | 0.81 | FABP3 (0.58) | GABRA1GABRB2FABP3FABP4ALDH1A1 | |
| Water SCHEMBL5706121 | 0.81 | FABP3 (0.58) | GABRA1GABRB2FABP3FABP4ALDH1A1 | |
| SCHEMBL6910525 | 0.81 | FABP3 (0.58) | GABRA1GABRB2FABP3FABP4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017131500-A1 | NOVEL COMPOUND HAVING HSP90 INHIBITORY ACTIVITY OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, AND MEDICAL USE THEREOF | 계명대학교 산학협력단 | 2017-08-03 | — | — | WO | disclosed |
| CN-103782242-B | Toner | 佳能株式会社 | 2017-06-23 | — | — | CN | disclosed |
| US-9618867-B2 | Pigment dispersion and toner | CANON KABUSHIKI KAISHA (JP) | 2017-04-11 | — | — | US | disclosed |
| US-20160246200-A1 | PIGMENT DISPERSION AND TONER | CANON KABUSHIKI KAISHA (JP) | 2016-08-25 | — | — | US | disclosed |
| EP-2753982-B1 | TONER | CANON KK (JP) | 2016-03-23 | — | — | EP | disclosed |
| US-9223240-B2 | Toner | CANON KABUSHIKI KAISHA (JP) | 2015-12-29 | — | — | US | disclosed |
| US-9079989-B2 | Charge control resin and manufacturing method of the same | ORIENT CHEMICAL INDUSTRIES CO., LTD. (JP) | 2015-07-14 | — | — | US | disclosed |
| US-20150025213-A1 | CHARGE CONTROL RESIN AND MANUFACTURING METHOD OF THE SAME | ORIENT CHEMICAL INDUSTRIES CO., LTD. (JP) | 2015-01-22 | — | — | US | disclosed |
| US-8883946-B2 | Charge control resin and manufacturing method of the same | ORIENT CHEMICAL INDUSTRIES CO., LTD. (JP) | 2014-11-11 | — | — | US | disclosed |
| US-20140205943-A1 | TONER | CANON KABUSHIKI KAISHA (JP) | 2014-07-24 | — | — | US | disclosed |
| US-7319101-B2 | COMT inhibitors for the treatment of depression and impaired cognition | HOFFMANN-LA ROCHE INC. (US) | 2008-01-15 | — | — | US | disclosed |
| US-7319101-B2 | COMT inhibitors for the treatment of depression and impaired cognition | HOFFMANN-LA ROCHE INC. (US) | 2008-01-15 | — | — | US | disclosed |
| US-7319101-B2 | COMT inhibitors for the treatment of depression and impaired cognition | HOFFMANN-LA ROCHE INC. (US) | 2008-01-15 | — | — | US | disclosed |
| EP-1697394-B1 | COMT INHIBITORS | HOFFMANN LA ROCHE (CH) | 2007-03-21 | — | — | EP | disclosed |
| EP-1697394-B1 | COMT INHIBITORS | HOFFMANN LA ROCHE (CH) | 2007-03-21 | — | — | EP | disclosed |
| CN-1886416-A | COMT inhibitors | HOFFMANN LA ROCHE (CH) | 2006-12-27 | — | — | CN | disclosed |
| EP-1697394-A2 | COMT INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2006-09-06 | — | — | EP | disclosed |
| WO-2005058228-A2 | COMT INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-06-30 | — | — | WO | disclosed |
| WO-2005058228-A2 | COMT INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-06-30 | — | — | WO | disclosed |
| US-20050137162-A1 | New COMT inhibitors for the treatment of depression and impaired cognition | F. HOFFMANN-LA ROCHE AG (CH) | 2005-06-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050137162-A1 | New COMT inhibitors for the treatment of depression and impaired cognition | COMT, MAOB, TPH1 | GABRA1 926/4885GABRB2 1460/4885FABP3 4312/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.