Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 11/20 | 0.56 |
| ▸ | DRD2 | P14416 | 11/20 | 0.56 |
| ▸ | HTR2A | P28223 | 11/20 | 0.56 |
| ▸ | HTR7 | P34969 | 8/20 | 0.56 |
| ▸ | HTR6 | P50406 | 8/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.54 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.54 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.54 |
| ▸ | HRH1 | P35367 | 2/20 | 0.54 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.54 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.54 |
| ▸ | DRD1 | P21728 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL268805 | 0.95 | HTR1A (0.55) | HTR1ADRD2HTR2AHTR7HTR6 | |
| SCHEMBL5669383 | 0.89 | HTR1A (0.51) | HTR1ADRD2HTR2AHTR7HTR6 | |
| SCHEMBL3521966 | 0.85 | DRD2 (0.53) | HTR1ADRD2HTR2AHTR7HTR6 | |
| SCHEMBL267903 | 0.85 | HTR1A (0.49) | HTR1ADRD2HTR2AHTR7HTR6 | |
| SCHEMBL267610 | 0.83 | HTR1A (0.52) | HTR1ADRD2HTR2AHTR7HTR6 | |
| SCHEMBL3517324 | 0.83 | HTR1A (0.52) | HTR1ADRD2HTR2AHTR7HTR6 | |
| SCHEMBL4350205 | 0.81 | HTR1A (0.50) | HTR1ADRD2HTR2AHTR7HTR6 | |
| SCHEMBL20456303 | 0.80 | HTR1A (0.48) | HTR1ADRD2HTR2AHTR7HTR6 | |
| SCHEMBL9379524 | 0.80 | HTR1A (0.48) | HTR1ADRD2HTR2AHTR7HTR6 | |
| SCHEMBL8242911 | 0.80 | HTR1A (0.48) | HTR1ADRD2HTR2AHTR7HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7332506-B2 | Substituted-3-indolyl-4-piperidino-alkyl heterocycles for the treatment of depression | WYETH (US) | 2008-02-19 | — | — | US | disclosed |
| US-20070049582-A1 | Substituted-3-indolyl-4-piperidino-alkyl heterocycles for the treatment of depression | WYETH (US) | 2007-03-01 | — | — | US | disclosed |
| US-7148235-B2 | Substituted-3-indolyl-4-piperidino-alkyl heterocycles for the treatment of depression | WYETH (US) | 2006-12-12 | — | — | US | disclosed |
| US-20050239775-A1 | Substituted-3-indolyl-4-piperidino-alkyl heterocycles for the treatment of depression | WYETH (US) | 2005-10-27 | — | — | US | disclosed |
| US-6939870-B2 | Substituted-3-indolyl-4-piperidino-alkyl heterocycles for the treatment of depression | WYETH (US) | 2005-09-06 | — | — | US | disclosed |
| US-20040204402-A1 | Substituted-3-indolyl-4-piperidino-alkyl heterocycles for the treatment of depression | WYETH | 2004-10-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040204402-A1 | Substituted-3-indolyl-4-piperidino-alkyl heterocycles for the treatment of depression | TPH1, TPH2, HTR1A | HTR1A 3/4885DRD2 25/4885HTR2A 11/4885 |
| US-20050239775-A1 | Substituted-3-indolyl-4-piperidino-alkyl heterocycles for the treatment of depression | TPH1, TPH2, HTR1A | HTR1A 3/4885DRD2 23/4885HTR2A 11/4885 |
| US-20070049582-A1 | Substituted-3-indolyl-4-piperidino-alkyl heterocycles for the treatment of depression | TPH1, TPH2, HTR1A | HTR1A 3/4885DRD2 23/4885HTR2A 11/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.