Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CTSB | P07858 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5071420 | 0.91 | TDP1 (0.57) | TDP1ALDH1A1CYP3A4ALOX15HSD17B10 | |
| SCHEMBL9078242 | 0.87 | TDP1 (0.57) | TDP1ALDH1A1CYP3A4ALOX15HSD17B10 | |
| SCHEMBL10526689 | 0.86 | TDP1 (0.74) | TDP1ALDH1A1CYP3A4ALOX15HSD17B10 | |
| SCHEMBL11811233 | 0.82 | TDP1 (0.71) | TDP1ALDH1A1CYP3A4ALOX15HSD17B10 | |
| SCHEMBL3192020 | 0.81 | TDP1 (0.46) | TDP1ALDH1A1CYP3A4ALOX15HSD17B10 | |
| SCHEMBL11358228 | 0.79 | ALDH1A1 (0.56) | TDP1ALDH1A1CYP3A4ALOX15HSD17B10 | |
| SCHEMBL11761651 | 0.79 | ALDH1A1 (0.45) | TDP1ALDH1A1CYP3A4ALOX15HSD17B10 | |
| SCHEMBL1379532 | 0.79 | TDP1 (0.61) | TDP1ALDH1A1CYP3A4ALOX15HSD17B10 | |
| SCHEMBL3193192 | 0.79 | TDP1 (0.75) | TDP1ALDH1A1CYP3A4ALOX15HSD17B10 | |
| SCHEMBL7912372 | 0.78 | TDP1 (0.67) | TDP1ALDH1A1CYP3A4ALOX15HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1552692-A | Preparation of 1-Cl-4,8-dinitronaphthalene and 4-cl-1,8-dinitronaphthalene | 姜日善 | 2004-12-08 | — | — | CN | claimed |
| US-20080009489-A1 | ANDROGEN RECEPTOR MODULATORS AND METHOD OF TREATING DISEASE USING THE SAME | ACADIAN PHARMACEUTICALS, INC. (US) | 2008-01-10 | — | — | US | disclosed |
| US-7268232-B2 | Androgen receptor modulators and method of treating disease using the same | ACADIA PHARMACEUTICALS INC. (US) | 2007-09-11 | — | — | US | disclosed |
| WO-2007092391-A1 | ANDROGEN RECEPTOR MODULATORS AND METHODS OF TREATING DISEASE USING THE SAME | ACADIA PHARMACEUTICALS INC. (US) | 2007-08-16 | — | — | WO | disclosed |
| EP-1756101-A2 | ANDROGEN RECEPTOR MODULATORS AND METHOD OF TREATING DISEASE USING THE SAME | Acadia Pharmaceuticals Inc. (US) | 2007-02-28 | — | — | EP | disclosed |
| US-20070004679-A1 | Androgen receptor modulators and methods of treating disease using the same | ACADIA PHARMACEUTICALS INC. | 2007-01-04 | — | — | US | disclosed |
| US-20060014739-A1 | Androgen receptor modulators and method of treating disease using the same | ACADIA PHARMACEUTICALS INC. | 2006-01-19 | — | — | US | disclosed |
| WO-2005115361-A2 | ANDROGEN RECEPTOR MODULATORS AND METHOD OF TREATING DISEASE USING THE SAME | ACADIA PHARMACEUTICALS INC. (US) | 2005-12-08 | — | — | WO | disclosed |
| CN-1552692-A | Preparation of 1-Cl-4,8-dinitronaphthalene and 4-cl-1,8-dinitronaphthalene | 姜日善 | 2004-12-08 | — | — | CN | disclosed |
| CN-1552692-A | Preparation of 1-Cl-4,8-dinitronaphthalene and 4-cl-1,8-dinitronaphthalene | 姜日善 | 2004-12-08 | — | — | CN | disclosed |
| CN-1552692-A | Preparation of 1-Cl-4,8-dinitronaphthalene and 4-cl-1,8-dinitronaphthalene | 姜日善 | 2004-12-08 | — | — | CN | disclosed |
| US-3953598-A | ASTHMA OR RHINITIS TREATMENT | THE UPJOHN COMPANY (US) | 1976-04-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060014739-A1 | Androgen receptor modulators and method of treating disease using the same | NR5A1, AR, CYP17A1 | TDP1 3459/4885ALDH1A1 427/4885CYP3A4 458/4885 |
| US-20070004679-A1 | Androgen receptor modulators and methods of treating disease using the same | NR5A1, AR, ESRRA | TDP1 3153/4885ALDH1A1 404/4885CYP3A4 641/4885 |
| US-20080009489-A1 | ANDROGEN RECEPTOR MODULATORS AND METHOD OF TREATING DISEASE USING THE SAME | NR5A1, AR, CYP17A1 | TDP1 3459/4885ALDH1A1 427/4885CYP3A4 458/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.