Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | KCNN4 | O15554 | 4/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6648589 | 0.66 | ALDH1A1 (0.35) | CYP2C19KMT2AHSD17B10 | |
| SCHEMBL17075133 | 0.62 | SIGMAR1 (0.34) | SIGMAR1CYP2C19TDP1KMT2AHSD17B10 | |
| SCHEMBL23513478 | 0.61 | HPGD (0.55) | SIGMAR1CYP2C19KCNN4KMT2AHSD17B10 | |
| SCHEMBL6936002 | 0.61 | BCHE (0.41) | SIGMAR1CYP2C19KMT2A | |
| SCHEMBL27876871 | 0.60 | BCHE (0.40) | SIGMAR1CYP2C19KMT2A | |
| Bromide SCHEMBL27893551 | 0.60 | BCHE (0.40) | SIGMAR1CYP2C19KMT2A | |
| SCHEMBL578197 | 0.60 | CES1 (0.62) | KMT2AHSD17B10 | |
| SCHEMBL29744465 | 0.59 | CA12 (0.68) | CYP2C19KMT2A | |
| SCHEMBL3281797 | 0.59 | CA12 (0.68) | CYP2C19KMT2A | |
| SCHEMBL4863503 | 0.58 | HRH1 (0.49) | SIGMAR1CYP2C19KCNN4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7141563-B2 | Process for the preparation of 1, 2, 3, 4, 8, 9, 10, 10a-octahydro-7bH-cyclopenta[b] [1, 4]diazepino[6, 7, 1-hi] indole derivatives | WYETH (US) | 2006-11-28 | — | — | US | claimed |
| US-20020058689-A1 | Process for the preparation of 1, 2, 3, 4, 8, 9, 10, 10a-octahydro-7bH-cyclopenta[b] [1, 4]diazepino[6, 7, 1-hi]indole derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 2002-05-16 | — | — | US | claimed |
| US-7351839-B2 | Process for the preparation of 1,2,3,4,8,9,10, 10a-octahydro-7bH-cyclopenta[b][1,4]diazepino-[6,7,1-hi]indole derivatives | WYETH (US) | 2008-04-01 | — | — | US | disclosed |
| US-20070066676-A1 | Process for the preparation of 1,2,3,4,8,9,10, 10a-octahydro-7bH-cyclopenta[b][1,4]diazepino-[6,7,1-hi]indole derivatives | WYETH (US) | 2007-03-22 | — | — | US | disclosed |
| US-7141563-B2 | Process for the preparation of 1, 2, 3, 4, 8, 9, 10, 10a-octahydro-7bH-cyclopenta[b] [1, 4]diazepino[6, 7, 1-hi] indole derivatives | WYETH (US) | 2006-11-28 | — | — | US | disclosed |
| EP-1330457-B1 | CYCLOPENTA[B][1,4] DIAZEPINO[6,7,1-HI]INDOLES AS 5HT2C ANTAGONISTS | WYETH CORP (US) | 2004-10-20 | — | — | EP | disclosed |
| EP-1330457-A2 | CYCLOPENTA[B][1,4] DIAZEPINO[6,7,1-HI]INDOLES AS 5HT2C ANTAGONISTS | Wyeth (US) | 2003-07-30 | — | — | EP | disclosed |
| WO-2002042304-A2 | CYCLOPENTA[B][1,4] DIAZEPINO[6,7,1-HI]INDOLES AS 5HT2C ANTAGONISTS | WYETH (US) | 2002-05-30 | — | — | WO | disclosed |
| US-20020058689-A1 | Process for the preparation of 1, 2, 3, 4, 8, 9, 10, 10a-octahydro-7bH-cyclopenta[b] [1, 4]diazepino[6, 7, 1-hi]indole derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 2002-05-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020058689-A1 | Process for the preparation of 1, 2, 3, 4, 8, 9, 10, 10a-octahydro-7bH-cyclopenta[b] [1, 4]diazepino[6, 7, 1-hi]indole derivatives | HRH3, HTR1A, HTR7 | SIGMAR1 422/4885CYP2C19 79/4885TDP1 3037/4885 |
| US-20070066676-A1 | Process for the preparation of 1,2,3,4,8,9,10, 10a-octahydro-7bH-cyclopenta[b][1,4]diazepino-[6,7,1-hi]indole derivatives | HRH4, HRH3, AHR | SIGMAR1 545/4885CYP2C19 67/4885TDP1 3711/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.