Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK5 | Q00535 | 8/20 | 0.41 |
| ▸ | CDK5R1 | Q15078 | 8/20 | 0.41 |
| ▸ | MMP12 | P39900 | 6/20 | 0.39 |
| ▸ | PIM1 | P11309 | 3/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.38 |
| ▸ | ULK1 | O75385 | 1/20 | 0.38 |
| ▸ | CDK7 | P50613 | 1/20 | 0.38 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.38 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.38 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.38 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.38 |
| ▸ | MAP3K19 | Q56UN5 | 1/20 | 0.38 |
| ▸ | CAMKK1 | Q8N5S9 | 1/20 | 0.38 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.38 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.35 |
| ▸ | PLAU | P00749 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3259988 | 0.80 | KDM4E (0.35) | KDM4EMAPTKMT2ANPC1GLA | |
| SCHEMBL1800839 | 0.80 | CDK5 (0.42) | CDK5CDK5R1MMP12PIM1MMP2 | |
| SCHEMBL28388664 | 0.77 | KDM4E (0.33) | KDM4EMAPTKMT2ANPC1GLA | |
| SCHEMBL4838743 | 0.77 | MAPT (0.37) | MMP12KDM4EMAPTKMT2ANPC1 | |
| SCHEMBL28888432 | 0.77 | MMP12 (0.45) | CDK5CDK5R1MMP12PIM1MMP2 | |
| SCHEMBL28389210 | 0.73 | XDH (0.33) | KDM4EMAPTKMT2AALDH1A1NPC1 | |
| SCHEMBL30610462 | 0.72 | NPC1 (0.46) | CDK5CDK5R1KDM4EMAPTKMT2A | |
| SCHEMBL30610461 | 0.72 | NPC1 (0.46) | CDK5CDK5R1KDM4EMAPTKMT2A | |
| SCHEMBL7878556 | 0.71 | NUDT1 (0.37) | CDK5CDK5R1PIM1DYRK1AULK1 | |
| Phenol SCHEMBL29093679 | 0.68 | MAPK14 (0.46) | KDM4EMAPTKMT2ANPC1GLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110950806-A | Preparation method of pyrimidine cyclic hydroxy chloride by catalysis of tetraethylammonium chloride | 安庆博曼生物技术有限公司 | 2020-04-03 | — | — | CN | claimed |
| CN-110950806-A | Preparation method of pyrimidine cyclic hydroxy chloride by catalysis of tetraethylammonium chloride | 安庆博曼生物技术有限公司 | 2020-04-03 | — | — | CN | disclosed |
| US-7390890-B2 | Inhibitors of nucleoside metabolism | ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY (US) | 2008-06-24 | — | — | US | disclosed |
| CN-100393722-C | Inhibitors of nucleoside metabolism | EINSTEIN COLL MED (US) | 2008-06-11 | — | — | CN | disclosed |
| US-20070197561-A1 | Inhibitors of nucleoside metabolism | BIOCRYST PHARMACEUTICALS, INC. | 2007-08-23 | — | — | US | disclosed |
| WO-2007069924-A1 | DEAZAPURINE ANALOGS OF 4'-AZA-L-NUCLEOSIDES | INDUSTRIAL RESEARCH LIMITED (NZ) | 2007-06-21 | — | — | WO | disclosed |
| US-7211653-B2 | Inhibitors of nucleoside metabolism | ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY (US) | 2007-05-01 | — | — | US | disclosed |
| CN-1757646-A | Inhibitors of nucleoside metabolism | EINSTEIN COLL MED (US) | 2006-04-12 | — | — | CN | disclosed |
| CN-1220695-C | Inhibitors of nucleoside metabolism | ALBERT EINSTEIN MEDICAL COLLAG (US) | 2005-09-28 | — | — | CN | disclosed |
| EP-1023308-B1 | INHIBITORS OF NUCLEOSIDE METABOLISM | EINSTEIN COLL MED (US) | 2005-09-07 | — | — | EP | disclosed |
| US-20050026936-A1 | Inhibitors of nucleoside metabolism | BIOCRYST PHARMACEUTICALS, INC. | 2005-02-03 | — | — | US | disclosed |
| US-6803455-B2 | PYRROLO(3,2-D)PYRIMIDIN-7-YL)-1,4-IMINO-D-RIBITOL DERIVATIVES; FOR SUPPRESSION OF T-CELL FUNCTION | ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY | 2004-10-12 | — | — | US | disclosed |
| US-20030096830-A1 | Inhibitors of nucleoside metabolism | BIOCRYST PHARMACEUTICALS, INC. | 2003-05-22 | — | — | US | disclosed |
| US-6492347-B2 | TREATMENT AND/OR PROPHYLAXIS OF INFECTION CAUSED BY PROTOZOAN PARASITE BY ADMINISTERING COMPOUND TO INHIBIT PURINE NUCLEOSIDE HYDROLASE, PURINE NUCLEOSIDE PHOSPHORYLASE, AND/OR PURINE PHOSPHORIBOSYL TRANSFERASE | ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY | 2002-12-10 | — | — | US | disclosed |
| US-20020061898-A1 | Inhibitors of nucleoside metabolism | BIOCRYST PHARMACEUTICALS, INC. | 2002-05-23 | — | — | US | disclosed |
| US-6228847-B1 | ADMINISTERING PYRROLO(3,2-D)PYRIMIDINE DERIVATIVES AS PURINE NUCLEOSIDE PHOSPHORYLASE INHIBITOR | ALBERT EINSTEIN COLLEGE OF MEDICINE | 2001-05-08 | — | — | US | disclosed |
| CN-1279686-A | Inhibitors of nucleoside metabolism | ALBERT EINSTEIN COLLAGE OF MED (US) | 2001-01-10 | — | — | CN | disclosed |
| US-6066722-A | Inhibitors of nucleoside metabolism | ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY (US) | 2000-05-23 | — | — | US | disclosed |
| US-5985848-A | EFFECTIVE INHIBITORS OF PURINE NUCLEOSIDE PHOSPHORYLASE AND/OR NUCLEOSIDE HYDROLASES; TREATMENT AND/OR PROPHYLAXIS OF A PROTOZOAN INFECTION | ALBERT EINSTEIN COLLEGE OF MEDICINE OF YESHIVA UNIVERSITY (US) | 1999-11-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050026936-A1 | Inhibitors of nucleoside metabolism | CFH, CBR3, SLCO2B1 | CDK5 2560/4885CDK5R1 2031/4885MMP12 4855/4885 |
| US-20020061898-A1 | Inhibitors of nucleoside metabolism | PNP, APRT, NUDT14 | CDK5 653/4885CDK5R1 1030/4885MMP12 2934/4885 |
| US-20070197561-A1 | Inhibitors of nucleoside metabolism | CFH, CBR3, SLCO2B1 | CDK5 2560/4885CDK5R1 2031/4885MMP12 4855/4885 |
| US-20030096830-A1 | Inhibitors of nucleoside metabolism | CFH, NADK, UGT1A3 | CDK5 3077/4885CDK5R1 2600/4885MMP12 4824/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.