SCHEMBL487256

SCHEMBL487256

B.CCc1ccc(C)nc1

nearest known ligand 0.57

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 3/20 0.46
KDM4E B2RXH2 2/20 0.46
SMN1; SMN2 Q16637 2/20 0.43
TSHR P16473 1/20 0.43
GAA P10253 1/20 0.43
MEN1 O00255 1/20 0.41
LMNA P02545 1/20 0.41
KMT2A Q03164 1/20 0.41
NPC1 O15118 1/20 0.41
RAB9A P51151 1/20 0.41
HRH3 Q9Y5N1 1/20 0.41
CYP1A2 P05177 2/20 0.40
CYP2D6 P10635 1/20 0.40
ELANE P08246 1/20 0.38
POLB P06746 1/20 0.38
CYP2E1 P05181 1/20 0.37
CYP2A6 P11509 1/20 0.37
CYP2B6 P20813 1/20 0.37
CYP2C19 P33261 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22685742 1.00 L3MBTL1 (0.46) L3MBTL1KDM4ESMN1; SMN2TSHRGAA
SCHEMBL24448 0.98
SCHEMBL29391736 0.98
Propane SCHEMBL28751201 0.95 L3MBTL1 (0.46) L3MBTL1KDM4ESMN1; SMN2TSHRGAA
Hydrochloric Acid SCHEMBL29018520 0.95 L3MBTL1 (0.46) L3MBTL1KDM4ESMN1; SMN2TSHRGAA
SCHEMBL29361262 0.95 L3MBTL1 (0.46) L3MBTL1KDM4ESMN1; SMN2TSHRGAA
Hydrochloric Acid SCHEMBL11591675 0.95 L3MBTL1 (0.46) L3MBTL1KDM4ESMN1; SMN2TSHRGAA
Water SCHEMBL29067376 0.95 L3MBTL1 (0.46) L3MBTL1KDM4ESMN1; SMN2TSHRGAA
SCHEMBL16594911 0.89 SMN1; SMN2 (0.44) L3MBTL1KDM4ESMN1; SMN2TSHRGAA
SCHEMBL3893320 0.84 CYP11B1 (0.42) L3MBTL1KDM4ESMN1; SMN2TSHRGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 580 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113874355-B Process for the manufacture of (6 AR,10 AR) -7-propyl-6, 6A,7,8,9, 10A, 11-octahydro- [1,3] dioxolo [4',5':5,6] benzo [1,2-G ] quinoline and (4 AR,10 AR) -1-propyl-1, 2,3, 4A,5, 10A-octahydro-benzo [ G ] quinoline-6, 7-diol H.隆德贝克有限公司 2024-07-30 CN claimed
US-20240018107-A1 PROCESS FOR THE MANUFACTURING OF (6AR,10AR)-7-PROPYL-6,6A,7,8,9,10,10A,11-OCTAHYDRO-[1,3]DIOXOLO[4',5':5,6]BENZO[1,2-G]QUINOLINE AND (4AR,10AR)-1-PROPYL-1,2,3,4,4A,5,10,10A-OCTAHYDRO-BENZO[G]QUINOLINE-6,7-DIOL H. LUNDBECK A/S (DK) 2024-01-18 US claimed
US-20230346903-A1 GROUP B STREPTOCOCCUS POLYSACCHARIDE-PROTEIN CONJUGATES, METHODS FOR PRODUCING CONJUGATES, IMMUNOGENIC COMPOSITIONS COMPRISING CONJUGATES, AND USES THEREOF PFIZER INC. (US) 2023-11-02 US claimed
WO-2023118207-A1 PROCESS FOR DYEING A CELLULOSIC MATERIAL PILI (FR) 2023-06-29 WO claimed
CN-114195902-B Recombinant protein structural domain enhanced TET enzyme and whole genome DNA methylation detection method 翌圣生物科技(上海)股份有限公司 2023-06-20 CN claimed
CN-114591439-B Recombinant TET enzyme MBD2-NgTET1 and application thereof in improving 5caC (cubic-alternating current) ratio in TET enzyme oxidation product 翌圣生物科技(上海)股份有限公司 2023-06-20 CN claimed
CN-114591440-B Recombinant TET enzyme MBD4-NgTET1 and application thereof in improving 5caC (cubic-alternating current) ratio in TET enzyme oxidation product 翌圣生物科技(上海)股份有限公司 2023-06-20 CN claimed
CN-114591441-B Recombinant TET enzyme MBD3-NgTET1 and application thereof in improving 5caC (cubic-alternating current) ratio in TET enzyme oxidation product 翌圣生物科技(上海)股份有限公司 2023-06-20 CN claimed
CN-115947646-A Method for photo-catalytic hydroxylation of aryl or heteroaryl halide 浙江工业大学 2023-04-11 CN claimed
WO-2022185599-A1 CARBONYLATED PROTEIN REDUCING AGENT FOR HAIR クラシエホームプロダクツ株式会社 2022-09-09 WO claimed
WO-2015123519-A2 PROCESSES FOR PREPARING FUSED HETEROCYCLIC ION CHANNEL MODULATORS GILEAD SCIENCES, INC. (US) 2015-08-20 WO claimed
EP-2906566-A1 PROCESS FOR MAKING THIENOPYRIMIDINE COMPOUNDS F. Hoffmann-La Roche AG (CH) 2015-08-19 EP claimed
CN-104844535-A Method for preparing condensed heterocyclic ion channel conditioning agent GILEAD SCIENCES INC 2015-08-19 CN claimed
US-20150225384-A1 PROCESSES FOR PREPARING FUSED HETEROCYCLIC ION CHANNEL MODULATORS GILEAD SCIENCES, INC. 2015-08-13 US claimed
US-8895729-B2 Process for making thienopyrimidine compounds GENENTECH, INC. (US) 2014-11-25 US claimed
US-20140128600-A1 METHODS FOR PREPARING NAPHTHYRIDINES BIONOMICS LIMITED (AU) 2014-05-08 US claimed
WO-2014056955-A1 PROCESS FOR MAKING THIENOPYRIMIDINE COMPOUNDS F. HOFFMANN-LA ROCHE AG (CH) 2014-04-17 WO claimed
US-20140100366-A1 PROCESS FOR MAKING THIENOPYRIMIDINE COMPOUNDS GENENTECH, INC. (US) 2014-04-10 US claimed
EP-2707367-A1 METHODS FOR PREPARING NAPHTHYRIDINES Bionomics Limited (AU) 2014-03-19 EP claimed
WO-2012151640-A1 METHODS FOR PREPARING NAPHTHYRIDINES BIONOMICS LIMITED (AU) 2012-11-15 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140128600-A1 METHODS FOR PREPARING NAPHTHYRIDINES NQO1, CYP1A1, IPO4 L3MBTL1 4878/4885KDM4E 3399/4885SMN1; SMN2 3903/4885
US-20240018107-A1 PROCESS FOR THE MANUFACTURING OF (6AR,10AR)-7-PROPYL-6,6A,7,8,9,10,10A,11-OCTAHYDRO-[1,3]DIOXOLO[4',5':5,6]BENZO[1,2-G]QUINOLINE AND (4AR,10AR)-1-PROPYL-1,2,3,4,4A,5,10,10A-OCTAHYDRO-BENZO[G]QUINOLINE-6,7-DIOL PARK7, SNCA, CYP1B1 L3MBTL1 2698/4885KDM4E 1034/4885SMN1; SMN2 330/4885
US-20150225384-A1 PROCESSES FOR PREPARING FUSED HETEROCYCLIC ION CHANNEL MODULATORS KCNN2, KCNJ2, KCNN1 L3MBTL1 4686/4885KDM4E 1924/4885SMN1; SMN2 834/4885
US-20140100366-A1 PROCESS FOR MAKING THIENOPYRIMIDINE COMPOUNDS MTOR, PIK3CD, PIK3CA L3MBTL1 3985/4885KDM4E 1457/4885SMN1; SMN2 1757/4885
US-20230346903-A1 GROUP B STREPTOCOCCUS POLYSACCHARIDE-PROTEIN CONJUGATES, METHODS FOR PRODUCING CONJUGATES, IMMUNOGENIC COMPOSITIONS COMPRISING CONJUGATES, AND USES THEREOF SIGLEC7, SIGLEC9, FCGR3B L3MBTL1 3989/4885KDM4E 2366/4885SMN1; SMN2 3027/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.