Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | TDO2 | P48775 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | AHR | P35869 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.35 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.33 |
| ▸ | GOT1 | P17174 | 1/20 | 0.33 |
| ▸ | MGAM | O43451 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5918466 | 0.82 | CASP1 (0.45) | MAPTGAAALDH1A1CASP1MAP4K4 | |
| SCHEMBL12993530 | 0.77 | CNR1 (0.47) | ALDH1A1KDM4E | |
| SCHEMBL11818693 | 0.76 | MAPT (0.46) | MAPTGAAALDH1A1KDM4EHTT | |
| SCHEMBL4867807 | 0.75 | AHR (0.42) | MAPTHTTSMN1; SMN2TDO2CASP1 | |
| SCHEMBL10537069 | 0.71 | SCN9A (0.40) | MAPTGAAALDH1A1KDM4EHTT | |
| SCHEMBL3561375 | 0.71 | TDO2 (0.40) | MAPTALDH1A1KDM4EHTTSMN1; SMN2 | |
| SCHEMBL11541651 | 0.70 | MAPT (0.53) | MAPTGAAALDH1A1KDM4EHTT | |
| SCHEMBL4469422 | 0.69 | ALDH1A1 (0.43) | MAPTGAAALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL11822056 | 0.69 | TDP1 (0.54) | MAPTGAAALDH1A1KDM4EHTT | |
| SCHEMBL11833039 | 0.68 | GAA (0.41) | MAPTGAAALDH1A1KDM4EHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7317012-B2 | Bicyclic heterocycles as cannabinoind-1 receptor modulators | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-01-08 | — | — | US | disclosed |
| US-7317012-B2 | Bicyclic heterocycles as cannabinoind-1 receptor modulators | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-01-08 | — | — | US | disclosed |
| US-7317012-B2 | Bicyclic heterocycles as cannabinoind-1 receptor modulators | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-01-08 | — | — | US | disclosed |
| WO-2006138656-A2 | BICYCLIC HETEROCYCLES AS CANNABINOID-1 RECEPTOR MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-12-28 | — | — | WO | disclosed |
| US-20060287322-A1 | Bicyclic heterocycles as cannabinoind-1 receptor modulators | BRISTOL-MYERS SQUIBB COMPANY | 2006-12-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060287322-A1 | Bicyclic heterocycles as cannabinoind-1 receptor modulators | CNR1, CNR2, GPR18 | MAPT 2587/4885GAA 4572/4885ALDH1A1 1157/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.