Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 6/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.49 |
| ▸ | DRD2 | P14416 | 3/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.44 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.43 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | F2 | P00734 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16416392 | 0.84 | KMT2A (0.76) | DRD3KCNH2KMT2APOLBCYP2D6 | |
| SCHEMBL29450073 | 0.84 | KMT2A (0.76) | DRD3KCNH2KMT2APOLBCYP2D6 | |
| SCHEMBL7454333 | 0.81 | DRD3 (0.65) | DRD3KCNH2KMT2APOLBCYP2D6 | |
| SCHEMBL16081233 | 0.81 | SIGMAR1 (0.45) | DRD3KCNH2KMT2APOLBSIGMAR1 | |
| SCHEMBL16081239 | 0.81 | SIGMAR1 (0.45) | DRD3KCNH2KMT2APOLBSIGMAR1 | |
| SCHEMBL9190064 | 0.80 | KEAP1 (0.38) | DRD3KCNH2CYP2D6SIGMAR1DRD2 | |
| SCHEMBL13987063 | 0.80 | DRD3 (0.56) | DRD3KCNH2KMT2APOLBCYP2D6 | |
| SCHEMBL17284643 | 0.79 | DRD3 (0.54) | DRD3KCNH2KMT2APOLBCYP2D6 | |
| SCHEMBL16081245 | 0.78 | SIGMAR1 (0.43) | DRD3KCNH2KMT2APOLBSIGMAR1 | |
| SCHEMBL16081243 | 0.78 | SIGMAR1 (0.43) | DRD3KCNH2KMT2APOLBSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7470703-B1 | Yohimbine derivatives and use thereof | THE UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION (US) | 2008-12-30 | — | — | US | disclosed |