Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 2/20 | 0.56 |
| ▸ | PGR | P06401 | 1/20 | 0.51 |
| ▸ | BRD1 | O95696 | 2/20 | 0.50 |
| ▸ | BRPF1 | P55201 | 2/20 | 0.50 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | HTR2A | P28223 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.44 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.44 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | SGK1 | O00141 | 3/20 | 0.43 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4870984 | 0.84 | PGR (0.48) | HTR6PGRL3MBTL1PTPN2PTPN1 | |
| SCHEMBL4873426 | 0.82 | PGR (0.55) | PGRTRIM24BRD4 | |
| SCHEMBL4866404 | 0.80 | HTR6 (0.55) | HTR6PGRMAPTHTR2AHTR2C | |
| SCHEMBL4868720 | 0.78 | MAPT (0.49) | HTR6PGRBRD1BRPF1MAPT | |
| SCHEMBL4866321 | 0.78 | ALDH1A1 (0.57) | MAPTL3MBTL1 | |
| SCHEMBL4874458 | 0.78 | ALDH1A1 (0.44) | HTR6TRIM24MAPTDRD2HTR2A | |
| SCHEMBL4876385 | 0.77 | HTR6 (0.49) | HTR6TRIM24MAPTDRD2HTR2A | |
| SCHEMBL4876689 | 0.77 | CES1 (0.54) | HTR6MAPTDRD2HTR2AHTR2C | |
| SCHEMBL4873695 | 0.77 | ALDH1A1 (0.58) | MAPTHTR2AHTR2CL3MBTL1 | |
| SCHEMBL4876786 | 0.75 | ALDH1A1 (0.56) | HTR6PGRBRD1BRPF1TRIM24 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7408067-B2 | Aza-cyclic compounds as modulators of acetylcholine receptors | MERCK + CO., INC. (US) | 2008-08-05 | — | — | US | disclosed |
| US-20050070520-A1 | Aza-cyclic compounds as modulators of acetylcholine receptors | MERCK SHARP & DOHME CORP. | 2005-03-31 | — | — | US | disclosed |
| EP-1467986-A1 | AZA-CYCLIC COMPOUNDS AS MODULATORS OF ACETYLCHOLINE RECEPTORS | ELI LILLY AND COMPANY (US) | 2004-10-20 | — | — | EP | disclosed |
| WO-2003062224-A1 | AZA-CYCLIC COMPOUNDS AS MODULATORS OF ACETYLCHOLINE RECEPTORS | ELI LILLY AND COMPANY (US) | 2003-07-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050070520-A1 | Aza-cyclic compounds as modulators of acetylcholine receptors | CHRNG, CHRNA4, CHRNB4 | HTR6 335/4885PGR 1466/4885BRD1 1370/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.