Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 5/20 | 0.70 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.70 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | CA2 | P00918 | 3/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.39 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.39 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.38 |
| ▸ | PRKCG | P05129 | 1/20 | 0.38 |
| ▸ | PRKCB | P05771 | 1/20 | 0.38 |
| ▸ | PRKCA | P17252 | 1/20 | 0.38 |
| ▸ | PRKCH | P24723 | 1/20 | 0.38 |
| ▸ | AKT1 | P31749 | 1/20 | 0.38 |
| ▸ | PRKCI | P41743 | 1/20 | 0.38 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.38 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.38 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Helium SCHEMBL27671015 | 0.98 | CYP3A4 (0.68) | CYP3A4L3MBTL1TSHRTDP1ATM | |
| Potassium Ion SCHEMBL27536653 | 0.98 | CYP3A4 (0.68) | CYP3A4L3MBTL1TSHRTDP1ATM | |
| Potassium Ion SCHEMBL28161845 | 0.98 | CYP3A4 (0.68) | CYP3A4L3MBTL1TSHRTDP1ATM | |
| Zinc Ion SCHEMBL1396930 | 0.96 | CYP3A4 (0.70) | CYP3A4L3MBTL1TSHRTDP1ATM | |
| SCHEMBL325357 | 0.96 | CYP3A4 (0.70) | CYP3A4L3MBTL1TSHRTDP1ATM | |
| SCHEMBL3965781 | 0.96 | CYP3A4 (0.70) | CYP3A4L3MBTL1TSHRTDP1ATM | |
| SCHEMBL3331708 | 0.96 | CYP3A4 (0.70) | CYP3A4L3MBTL1TSHRTDP1ATM | |
| SCHEMBL22638109 | 0.96 | CYP3A4 (0.70) | CYP3A4L3MBTL1TSHRTDP1ATM | |
| SCHEMBL3959363 | 0.96 | CYP3A4 (0.70) | CYP3A4L3MBTL1TSHRTDP1ATM | |
| SCHEMBL673699 | 0.96 | CYP3A4 (0.70) | CYP3A4L3MBTL1TSHRTDP1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110843302-A | Bidirectional flame-retardant waterproof coating | 苏州市亚摩斯纺织涂层整理有限公司 | 2020-02-28 | — | — | CN | claimed |
| CN-108752098-A | A kind of boron-rich potassium diammonium phosphate fertilizer of cumulative chelated zinc and preparation method thereof | 天津富成源肥业有限公司 | 2018-11-06 | — | — | CN | claimed |
| CN-106316923-A | Disubstituted indol-2(1H)-one derivative and preparation method and application thereof | 中南大学 | 2017-01-11 | — | — | CN | claimed |
| US-4221572-A | Abrasive material having a polycarbodiimide and polyurethane resin binder | KAO SOAP COMPANY (JP) | 1980-09-09 | — | — | US | claimed |
| CN-111519441-A | Skin-care coating and preparation method and application thereof | 罗莱生活科技股份有限公司 | 2020-08-11 | — | — | CN | disclosed |
| CN-111249167-A | Sea salt cleaning scrub cream and preparation method thereof | 郑晓梅 | 2020-06-09 | — | — | CN | disclosed |
| CN-110843302-A | Bidirectional flame-retardant waterproof coating | 苏州市亚摩斯纺织涂层整理有限公司 | 2020-02-28 | — | — | CN | disclosed |
| CN-105934246-B | Tetrahydroquinoline compositions as BET bromodomain inhibitors | 福马疗法公司 | 2019-10-22 | — | — | CN | disclosed |
| CN-105142730-B | Eutectic formulation of cyclobenzaprine hydrochloride and amitriptyline hydrochloride | 通尼克斯制药有限公司 | 2019-04-16 | — | — | CN | disclosed |
| EP-2902385-B1 | DEPROTECTION METHOD FOR TETRAZOLE COMPOUND | API CORP (JP) | 2019-01-09 | — | — | EP | disclosed |
| EP-2891650-B1 | METHOD FOR PRODUCING BIARYL COMPOUND | API CORP (JP) | 2018-08-01 | — | — | EP | disclosed |
| CN-108348469-A | Therapeutic compositions | 德马克有限责任公司 | 2018-07-31 | — | — | CN | disclosed |
| US-5436223-A | Argricultural formulations comprising fluroxypyr esters which are liquid at 25° C. | DOWELANCO (US) | 1995-07-25 | — | — | US | disclosed |
| EP-0647096-A1 | AGRICULTURAL FORMULATIONS CONTAINING LIQUID ESTERS OF FLUROXYPYR | DOWELANCO (US) | 1995-04-12 | — | — | EP | disclosed |
| US-5374603-A | Herbicides | DOWELANCO (US) | 1994-12-20 | — | — | US | disclosed |
| WO-1994024866-A1 | AGRICULTURAL FORMULATIONS | DOWELANCO (US) | 1994-11-10 | — | — | WO | disclosed |
| US-4988365-A | Eliminates need for alkali or reducing agent for subsequent dyeing | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-01-29 | — | — | US | disclosed |
| US-4806126-A | PRETREATING WITH WETTING AGENT AND REACTION PRODUCT OF POLYETHYLENIMINE AND BIFUNCTIONAL ALKLATING AGENT | HOECHST AKTIENGESELLSCHAFT (DE) | 1989-02-21 | — | — | US | disclosed |
| US-4300903-A | WHEREIN THE AUXILIARIES ARE ORGANOPHOSPHATE SALTS, ORGANOSULFONATES OR ETHYLENE OXIDE-PROPYLENE OXIDE COPOLYMER | CASSELLA AKTIENGESELLSCHAFT (DE) | 1981-11-17 | — | — | US | disclosed |
| US-4221572-A | Abrasive material having a polycarbodiimide and polyurethane resin binder | KAO SOAP COMPANY (JP) | 1980-09-09 | — | — | US | disclosed |