Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIN1 | Q13526 | 2/20 | 0.50 |
| ▸ | PPARG | P37231 | 13/20 | 0.46 |
| ▸ | PPARA | Q07869 | 12/20 | 0.46 |
| ▸ | APP | P05067 | 2/20 | 0.43 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.41 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.40 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.40 |
| ▸ | ERN1 | O75460 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4872018 | 1.00 | PIN1 (0.50) | PIN1PPARGPPARAAPPTNFRSF1A | |
| SCHEMBL4873628 | 1.00 | PIN1 (0.50) | PIN1PPARGPPARAAPPTNFRSF1A | |
| SCHEMBL4872015 | 1.00 | PIN1 (0.50) | PIN1PPARGPPARAAPPTNFRSF1A | |
| SCHEMBL4872021 | 0.83 | PIN1 (0.50) | PIN1PPARGPPARATNFRSF1AERN1 | |
| SCHEMBL4868233 | 0.81 | PPARG (0.47) | PPARGPPARA | |
| SCHEMBL5599872 | 0.81 | PPARG (0.47) | PPARGPPARA | |
| SCHEMBL12130114 | 0.80 | PPARG (0.44) | PPARGPPARAAPPTNFRSF1AERN1 | |
| SCHEMBL1435567 | 0.79 | PPARG (0.57) | PPARGPPARA | |
| SCHEMBL4875934 | 0.76 | PPARA (0.58) | PPARGPPARA | |
| SCHEMBL4875939 | 0.76 | PPARA (0.58) | PPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7465752-B2 | Pentenoic acid derivatives, processes for the preparation thereof, pharmaceutical compositions comprising them, and therapeutic applications thereof | MERCK PATENT GMBH (DE) | 2008-12-16 | — | — | US | disclosed |
| US-20080015253-A1 | Pentenoic Acid Derivatives, Processes For The Preparation Thereof, Pharmaceutical Compositions Comprising Them, And Therapeutic Applications Thereof | MERCK PATENT GMBH (DE) | 2008-01-17 | — | — | US | disclosed |
| EP-1742903-B1 | PENTENOIC ACID DERIVATIVES, PROCESSES FOR THE PREPARATION THEREOF, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM, AND THERAPEUTIC APPLICATIONS THEREOF | MERCK PATENT GMBH (DE) | 2007-08-22 | — | — | EP | disclosed |
| EP-1742903-A1 | PENTENOIC ACID DERIVATIVES, PROCESSES FOR THE PREPARATION THEREOF, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM, AND THERAPEUTIC APPLICATIONS THEREOF | MERCK PATENT GmbH (DE) | 2007-01-17 | — | — | EP | disclosed |
| WO-2005105723-A1 | PENTENOIC ACID DERIVATIVES, PROCESSES FOR THE PREPARATION THEREOF, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM, AND THERAPEUTIC APPLICATIONS THEREOF | MERCK PATENT GMBH (DE) | 2005-11-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080015253-A1 | Pentenoic Acid Derivatives, Processes For The Preparation Thereof, Pharmaceutical Compositions Comprising Them, And Therapeutic Applications Thereof | ALOX5, GPR119, ALOX15B | PIN1 4452/4885PPARG 110/4885PPARA 62/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.