SCHEMBL4874802

SCHEMBL4874802

NC1(N)NC(=O)c2nccnc2N1

nearest known ligand 0.30

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.30
SMN1; SMN2 Q16637 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30141653 0.73
SCHEMBL30141656 0.70
SCHEMBL30642415 0.68
SCHEMBL841473 0.68 TNKS2 (0.30)
SCHEMBL15386158 0.66 ALDH1A1 (0.35) CYP1A2SMN1; SMN2
SCHEMBL3500581 0.65 ALDH1A1 (0.37) CYP1A2SMN1; SMN2
SCHEMBL21586265 0.64 ALDH1A1 (0.30)
SCHEMBL3028579 0.60 GSK3B (0.32)
SCHEMBL8871604 0.59 LMNA (0.31)
SCHEMBL8613496 0.58 SMN1; SMN2 (0.34) CYP1A2SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113166065-B Compounds and compositions for treating disorders associated with NLRP activity 诺华股份有限公司 2025-04-15 CN disclosed
CN-114276349-B 2-aminopterine derivatives or salts thereof, and preparation method and application thereof 复旦大学 2024-04-09 CN disclosed
CN-117836427-A Polynucleotide sequencing 因美纳有限公司 2024-04-05 CN disclosed
CN-111094242-B Compounds and compositions for treating disorders associated with NLRP activity 诺华股份有限公司 2024-02-09 CN disclosed
CN-117209447-A Compounds and compositions for treating disorders associated with NLRP activity 诺华股份有限公司 2023-12-12 CN disclosed
CN-117143042-A Compounds and compositions for treating disorders associated with NLRP activity 诺华股份有限公司 2023-12-01 CN disclosed
CN-111094243-B Compounds and compositions for treating disorders associated with NLRP activity 诺华股份有限公司 2023-09-05 CN disclosed
CN-109923106-B toll-like receptor modulator compounds 吉利德科学公司 2022-09-13 CN disclosed
CN-113613721-A NLRP modulators 诺华股份有限公司 2021-11-05 CN disclosed
CN-113347970-A Compounds and compositions for treating conditions associated with NLRP activity 诺华股份有限公司 2021-09-03 CN disclosed
CN-113056451-A Compounds and compositions for treating conditions associated with NLRP activity 诺华股份有限公司 2021-06-29 CN disclosed
CN-113015730-A Compounds and compositions for treating conditions associated with NLRP activity 诺华股份有限公司 2021-06-22 CN disclosed
CN-112654350-A Methods of treating a subject resistant to a TNF inhibitor or selecting a treatment for said subject using an NLRP3 antagonist 诺华股份有限公司 2021-04-13 CN disclosed
CN-112584899-A NLRP modulators 诺华股份有限公司 2021-03-30 CN disclosed
CN-112424352-A Oligonucleotide conjugates comprising 7 '-5' -alpha-anomeric bicyclic sugar nucleosides 阿尔法阿诺麦里克公司 2021-02-26 CN disclosed
US-7354754-B2 Microorganism sensitive to lysozyme NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY (JP) 2008-04-08 US disclosed
US-20060166312-A1 Novel microorgnaism sensitive to lysozyme NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY (JP) 2006-07-27 US disclosed
EP-0322748-B1 Antibiotic NK86-0279, process for production of the same and application of the same NIPPON KAYAKU KK (JP) 1994-04-20 EP disclosed
US-5003056-A Fungicides, insecticides, antitumor agents, and vascularizations inhibitors NIPPON KAYAKU KABUSHIKI KAISHA (JP) 1991-03-26 US disclosed
EP-0322748-A1 Antibiotic NK86-0279, process for production of the same and application of the same NIPPON KAYAKU KABUSHIKI KAISHA (JP) 1989-07-05 EP disclosed