Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 2/20 | 0.35 |
| ▸ | TDP2 | O95551 | 1/20 | 0.35 |
| ▸ | NSD2 | O96028 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.35 |
| ▸ | CES1 | P23141 | 1/20 | 0.35 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.35 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | ADK | P55263 | 1/20 | 0.33 |
| ▸ | PLK4 | O00444 | 1/20 | 0.32 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.32 |
| ▸ | LCK | P06239 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8871432 | 0.82 | ALDH1A1 (0.31) | ALDH1A1 | |
| SCHEMBL11687696 | 0.82 | ALDH1A1 (0.31) | ALDH1A1 | |
| SCHEMBL4121156 | 0.75 | MAOA (0.43) | ALDH1A1GSK3BTDP2NSD2ABL1 | |
| SCHEMBL43437 | 0.73 | TDP2 (0.56) | ALDH1A1GSK3BTDP2NSD2ABL1 | |
| SCHEMBL15386158 | 0.71 | ALDH1A1 (0.35) | ALDH1A1TDP2NSD2ABL1PLCG1 | |
| SCHEMBL17159951 | 0.69 | ALDH1A1 (0.55) | ALDH1A1TDP2NSD2ABL1PLCG1 | |
| SCHEMBL23794347 | 0.67 | PPOX (0.41) | ALDH1A1GSK3BABL1MEN1BLM | |
| SCHEMBL14380284 | 0.67 | ALDH1A1 (0.36) | ALDH1A1TDP2NSD2ABL1PLCG1 | |
| SCHEMBL18050892 | 0.66 | ALDH1A1 (0.44) | ALDH1A1MEN1BLMKMT2A | |
| SCHEMBL7754905 | 0.66 | LMNA (0.31) | ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 51 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113164409-B | Compounds having estrogen receptor alpha degrading activity and uses thereof | 冰洲石生物科技公司 | 2023-07-18 | — | — | CN | claimed |
| EP-3675839-B1 | NOVEL COMPOUNDS HAVING ESTROGEN RECEPTOR ALPHA DEGRADATION ACTIVITY AND USES THEREOF | ACCUTAR BIOTECHNOLOGY INC (US) | 2023-03-01 | — | — | EP | claimed |
| CN-114249683-A | Synthesis method of N-hydroxyimide compound | 中国石化扬子石油化工有限公司 | 2022-03-29 | — | — | CN | claimed |
| US-7019026-B1 | Modulators of Protein Tyrosine Phosphatases (PTPases) | NOVO NORDISK A/S (DK) | 2006-03-28 | — | — | US | claimed |
| EP-1214325-B1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPases) | NOVO NORDISK AS (DK) | 2005-11-09 | — | — | EP | claimed |
| EP-1214325-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPases) | NOVO NORDISK A/S (DK) | 2002-06-19 | — | — | EP | claimed |
| WO-2001019831-A1 | MODULATORS OF PROTEIN TYROSINE PHOSPHATASES (PTPases) | NOVO NORDISK A/S (DK) | 2001-03-22 | — | — | WO | claimed |
| EP-0229391-B1 | PIPERIDINE DERIVATE, ITS USE AND PHARMACEUTICAL COMPOSITION CONTAINING IT | Eisai Co., Ltd. (JP) | 1992-07-29 | — | — | EP | claimed |
| US-5118684-A | For cardiovascular disorder | EISAI CO., LTD. (JP) | 1992-06-02 | — | — | US | claimed |
| EP-0229391-A1 | Piperidine derivate, its use and pharmaceutical composition containing it | Eisai Co., Ltd. (JP) | 1987-07-22 | — | — | EP | claimed |
| JP-57142984-A | — | — | None | — | — | JP | disclosed |
| CN-117050002-A | Novel compounds having estrogen receptor alpha degrading activity and uses thereof | 冰洲石生物科技公司 | 2023-11-14 | — | — | CN | disclosed |
| CN-113164409-B | Compounds having estrogen receptor alpha degrading activity and uses thereof | 冰洲石生物科技公司 | 2023-07-18 | — | — | CN | disclosed |
| CN-116234803-A | Combinations of estrogen receptor degrading agents and cyclin-dependent kinase inhibitors for the treatment of cancer | 冰洲石生物科技公司 | 2023-06-06 | — | — | CN | disclosed |
| US-20210139651-A1 | QUINOID CONJUGATED POLYMER AND PREPARATION METHOD AND APPLICATION THEREOF | DONGGUAN UNIVERSITY OF TECHNOLOGY (CN) | 2021-05-13 | — | — | US | disclosed |
| US-4849431-A | ANTICHOLINESTERASE ACTIVITY | EISAI CO., LTD. (JP) | 1989-07-18 | — | — | US | disclosed |
| EP-0229391-A1 | Piperidine derivate, its use and pharmaceutical composition containing it | Eisai Co., Ltd. (JP) | 1987-07-22 | — | — | EP | disclosed |
| JP-S57142984-A | NOVEL 2,3-PYRAZINEDICARBOXYLIC IMIDE A | HARA HIROSHI | 1982-09-03 | — | — | JP | disclosed |
| US-4193979-A | Sodium 3-[[[2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl]-amino]carbonyl]-2-pyridinecarboxylic acid and related compounds labeled with technetium-99m | G. D. SEARLE & CO. (US) | 1980-03-18 | — | — | US | disclosed |
| US-3960877-A | PLANT GROWTH REGULATOR, WEED KILLER DEFOLIATING AGENTS | THE SHERWIN-WILLIAMS COMPANY (US) | 1976-06-01 | — | — | US | disclosed |