Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 7/20 | 0.34 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.34 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.34 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 6/20 | 0.33 |
| ▸ | IDH1 | O75874 | 3/20 | 0.33 |
| ▸ | PER2 | O15055 | 1/20 | 0.32 |
| ▸ | CRY2 | Q49AN0 | 1/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6330433 | 0.71 | MAPK14 (0.36) | MAPK14MAPK13MAPK12MAPK11P2RX7 | |
| SCHEMBL4877486 | 0.70 | MAPK14 (0.34) | MAPK14MAPK13MAPK12MAPK11P2RX7 | |
| SCHEMBL6328151 | 0.65 | MAPK14 (0.37) | MAPK14MAPK13MAPK12MAPK11P2RX7 | |
| SCHEMBL6337204 | 0.65 | MAPK14 (0.37) | MAPK14MAPK13MAPK12MAPK11P2RX7 | |
| SCHEMBL6333145 | 0.65 | MAPK14 (0.34) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL6328812 | 0.64 | MAPK14 (0.38) | MAPK14MAPK13MAPK12MAPK11P2RX7 | |
| SCHEMBL4878743 | 0.62 | MAPK14 (0.37) | MAPK14MAPK13MAPK12MAPK11P2RX7 | |
| SCHEMBL3557651 | 0.62 | ALDH1A1 (0.43) | P2RX7NOTUMKMT2A | |
| SCHEMBL375276 | 0.61 | NOTUM (0.44) | P2RX7NOTUMKMT2A | |
| SCHEMBL6335578 | 0.60 | MAPK14 (0.39) | MAPK14MAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080081825-A1 | Nitrogen-Containing Heterocyclic Compounds and Medicinal Use Thereof | ONO PHARMACEUTICAL CO., LTD. (JP) | 2008-04-03 | — | — | US | disclosed |
| EP-1741702-A1 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUNDS AND MEDICINAL USE THEREOF | ONO PHARMACEUTICAL CO., LTD. (JP) | 2007-01-10 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080081825-A1 | Nitrogen-Containing Heterocyclic Compounds and Medicinal Use Thereof | MAPK1, NOS1, NOS2 | MAPK14 13/4885MAPK13 12/4885MAPK12 28/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.