Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP3 | P42574 | 1/20 | 0.68 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.68 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.68 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.68 |
| ▸ | CHEK2 | O96017 | 3/20 | 0.58 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.49 |
| ▸ | ITK | Q08881 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.43 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.43 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.43 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.43 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4869950 | 0.88 | CHEK2 (0.56) | CASP3SENP8SENP7SENP6CHEK2 | |
| SCHEMBL14904717 | 0.82 | CYP19A1 (0.69) | CASP3SENP8SENP7SENP6CYP19A1 | |
| SCHEMBL3704691 | 0.81 | CASP3 (1.00) | CASP3SENP8SENP7SENP6CHEK2 | |
| SCHEMBL29941485 | 0.81 | CASP3 (1.00) | CASP3SENP8SENP7SENP6CHEK2 | |
| SCHEMBL4867874 | 0.79 | MMP13 (0.59) | CASP3SENP8SENP7SENP6CYP19A1 | |
| SCHEMBL2244487 | 0.79 | CYP19A1 (0.78) | CASP3SENP8SENP7SENP6CYP19A1 | |
| SCHEMBL14213705 | 0.78 | CASP3 (0.71) | CASP3SENP8SENP7SENP6CHEK2 | |
| SCHEMBL4871800 | 0.77 | CYP19A1 (0.59) | CHEK2CYP19A1 | |
| SCHEMBL5635182 | 0.77 | NPC1 (0.73) | CASP3SENP8SENP7SENP6CYP19A1 | |
| SCHEMBL5438780 | 0.77 | CHEK2 (0.70) | CASP3SENP8SENP7SENP6CHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7375118-B2 | Phenyl-indole compounds for modulating IgE and Inhibiting cellular proliferation | AVANIR PHARMACEUTICALS (US) | 2008-05-20 | — | — | US | disclosed |
| EP-1537079-A4 | PHENYL-INDOLE COMPOUNDS FOR MODULATING IgE AND INHIBITING CELLULAR PROLIFERATION | AVANIR PHARMACEUTICALS (US) | 2007-05-16 | — | — | EP | disclosed |
| CN-1694868-A | Phenyl-indole compounds for modulating IgE and inhibiting cell proliferation | AVANIR PHARMACEUTICALS (US) | 2005-11-09 | — | — | CN | disclosed |
| EP-1537079-A2 | PHENYL-INDOLE COMPOUNDS FOR MODULATING IgE AND INHIBITING CELLULAR PROLIFERATION | AVANIR PHARMACEUTICALS (US) | 2005-06-08 | — | — | EP | disclosed |
| US-20040180946-A1 | Phenyl-indole compounds for modulating IgE and inhibiting cellular proliferation | AVANIR PHARMACEUTICALS | 2004-09-16 | — | — | US | disclosed |
| WO-2004024896-A2 | PHENYL-INDOLE COMPOUNDS | AVANIR PHARMACEUTICALS (US) | 2004-03-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040180946-A1 | Phenyl-indole compounds for modulating IgE and inhibiting cellular proliferation | IDO1, IDO2, CMA1 | CASP3 2022/4885SENP8 3860/4885SENP7 3584/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.