Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR1 | P21453 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | AURKA | O14965 | 2/20 | 0.44 |
| ▸ | EGFR | P00533 | 5/20 | 0.43 |
| ▸ | ERBB3 | P21860 | 5/20 | 0.43 |
| ▸ | FLT3 | P36888 | 3/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.41 |
| ▸ | KMO | O15229 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 2/20 | 0.40 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | BCR | P11274 | 1/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5284948 | 0.92 | FLT3 (0.41) | S1PR1NPC1RAB9AAURKAEGFR | |
| SCHEMBL4879483 | 0.87 | EGFR (0.49) | S1PR1NPC1RAB9AEGFRERBB3 | |
| SCHEMBL5283878 | 0.83 | CES2 (0.42) | S1PR1NPC1RAB9AEGFRERBB3 | |
| SCHEMBL5283876 | 0.81 | EGFR (0.43) | S1PR1NPC1RAB9AEGFRERBB3 | |
| SCHEMBL4872523 | 0.75 | NPC1 (0.57) | NPC1RAB9AAURKAEGFRERBB3 | |
| SCHEMBL4724653 | 0.75 | NPC1 (0.55) | NPC1RAB9AAURKAEGFRERBB3 | |
| SCHEMBL1070555 | 0.74 | GPR119 (0.47) | S1PR1EGFRFLT3CDK2CDK6 | |
| SCHEMBL5244511 | 0.73 | NPC1 (0.56) | NPC1RAB9AAURKAEGFRERBB3 | |
| SCHEMBL1830976 | 0.73 | GPR119 (0.45) | EGFRFLT3CDK2CDK6GPR119 | |
| SCHEMBL4873959 | 0.71 | AURKA (0.50) | NPC1RAB9AAURKAEGFRERBB3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080076771-A1 | Thrombopoietin Receptor Agonists | REITER LAWRENCE A | 2008-03-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080076771-A1 | Thrombopoietin Receptor Agonists | MPL, THPO, TBXA2R | S1PR1 327/4885NPC1 4382/4885RAB9A 2219/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.