Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CES1 | P23141 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 5/20 | 0.41 |
| ▸ | ERBB3 | P21860 | 5/20 | 0.41 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 3/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5283876 | 0.96 | EGFR (0.43) | CES2LMNACES1EGFRERBB3 | |
| SCHEMBL4877863 | 0.83 | S1PR1 (0.46) | EGFRERBB3S1PR1FLT3CDK2 | |
| SCHEMBL4879483 | 0.78 | EGFR (0.49) | EGFRERBB3S1PR1KDM4EFLT3 | |
| SCHEMBL5284948 | 0.76 | FLT3 (0.41) | EGFRERBB3S1PR1FLT3CDK2 | |
| SCHEMBL1983176 | 0.74 | LMNA (0.59) | CES2LMNACES1KDM4EALDH1A1 | |
| SCHEMBL1983175 | 0.69 | LMNA (0.59) | CES2LMNACES1KDM4EALDH1A1 | |
| SCHEMBL1830976 | 0.68 | GPR119 (0.45) | EGFRFLT3CDK2CDK6MEN1 | |
| Benzoin SCHEMBL8974816 | 0.64 | CES2 (0.91) | CES2LMNACES1KDM4EALDH1A1 | |
| Benzoin SCHEMBL901258 | 0.64 | CES2 (1.00) | CES2LMNACES1KDM4EALDH1A1 | |
| Benzoin SCHEMBL145 | 0.64 | CES2 (1.00) | CES2LMNACES1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1794156-A2 | TROMBOPOIETIN RECEPTOR AGONISTS | Pfizer Products Incorporated (US) | 2007-06-13 | — | — | EP | disclosed |
| WO-2006033005-A2 | THROMBOPOIETIN RECEPTOR AGONISTS | PFIZER PRODUCTS INC. (US) | 2006-03-30 | — | — | WO | disclosed |