Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 3/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 6/20 | 0.40 |
| ▸ | ERBB3 | P21860 | 6/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 2/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | BCR | P11274 | 1/20 | 0.36 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.36 |
| ▸ | KMO | O15229 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4877863 | 0.92 | S1PR1 (0.46) | FLT3CDK2CDK6EGFRERBB3 | |
| SCHEMBL4879483 | 0.80 | EGFR (0.49) | FLT3CDK2CDK6EGFRERBB3 | |
| SCHEMBL5283878 | 0.76 | CES2 (0.42) | FLT3CDK2CDK6EGFRERBB3 | |
| Terephthalic Acid SCHEMBL31485057 | 0.70 | TSHR (0.55) | — | |
| Terephthalic Acid SCHEMBL87786 | 0.70 | TSHR (0.55) | — | |
| SCHEMBL4724653 | 0.69 | NPC1 (0.55) | EGFRERBB3NPC1RAB9AAURKA | |
| SCHEMBL4872523 | 0.69 | NPC1 (0.57) | EGFRERBB3NPC1RAB9AAURKA | |
| SCHEMBL1070555 | 0.68 | GPR119 (0.47) | FLT3CDK2CDK6EGFRS1PR1 | |
| SCHEMBL5244511 | 0.68 | NPC1 (0.56) | EGFRERBB3NPC1RAB9AAURKA | |
| Terephthalic Acid SCHEMBL28820897 | 0.67 | TSHR (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1794156-A2 | TROMBOPOIETIN RECEPTOR AGONISTS | Pfizer Products Incorporated (US) | 2007-06-13 | — | — | EP | disclosed |
| WO-2006033005-A2 | THROMBOPOIETIN RECEPTOR AGONISTS | PFIZER PRODUCTS INC. (US) | 2006-03-30 | — | — | WO | disclosed |