SCHEMBL4877942

SCHEMBL4877942

O=C(O)Cn1c(-c2ccc3nc(-c4cccc(OC(F)(F)F)c4)ccc3c2)c(-c2ccccc2)c2sc(C(=O)O)cc21

nearest known ligand 0.38

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
STK17B O94768 1/20 0.38
PTGES O14684 1/20 0.37
FFAR1 O14842 1/20 0.36
FFAR4 Q5NUL3 1/20 0.36
PTGDR2 Q9Y5Y4 1/20 0.36
DYRK1A Q13627 2/20 0.36
MGLL Q99685 1/20 0.36
ALOX5AP P20292 2/20 0.35
ACP1 P24666 1/20 0.35
DHODH Q02127 1/20 0.34
SERPINE1 P05121 1/20 0.34
LDHA P00338 1/20 0.34
PIM1 P11309 1/20 0.34
PIM2 Q9P1W9 1/20 0.34
CTSA P10619 2/20 0.33
SLC13A5 Q86YT5 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4867738 0.88 PTGES (0.42) PTGESDYRK1AALOX5APSERPINE1
SCHEMBL4877910 0.87 ALOX5AP (0.36) STK17BFFAR1FFAR4MGLLALOX5AP
SCHEMBL4868351 0.86 AKR1A1 (0.35) DHODH
SCHEMBL4875109 0.86 PTGES (0.43) STK17BPTGESFFAR1FFAR4PTGDR2
SCHEMBL4867012 0.86 ACHE (0.36) MGLLALOX5APACP1PIM1
SCHEMBL4873965 0.80 GRIN2B (0.41)
SCHEMBL4867714 0.80 KDM4E (0.38) PTGDR2CTSA
SCHEMBL4874047 0.80 TP53 (0.44) ACP1
SCHEMBL4876042 0.79 KDM4E (0.36) PTGDR2
SCHEMBL4876355 0.79 GRIN2B (0.39) ALOX5AP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080051384-A1 ANTIVIRAL AGENTS GENELABS TECHNOLOGIES, INC. 2008-02-28 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080051384-A1 ANTIVIRAL AGENTS EIF2AK2, MAVS, ZC3HAV1 STK17B 4222/4885PTGES 3002/4885FFAR1 3762/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.