Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | BCHE | P06276 | 5/20 | 0.47 |
| ▸ | ACHE | P22303 | 5/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.45 |
| ▸ | PHLPP2 | Q6ZVD8 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | EGFR | P00533 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27975595 | 0.83 | LMNA (0.57) | KMT2AMEN1ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL3363874 | 0.81 | CYP2D6 (0.52) | CYP2D6BCHEACHECHRM1KMT2A | |
| SCHEMBL8330995 | 0.80 | MEN1 (0.62) | KMT2AMEN1ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL11937431 | 0.80 | CHRM1 (0.50) | BCHECHRM1PHLPP2EGFRALDH1A1 | |
| SCHEMBL27946955 | 0.79 | CES2 (0.50) | KMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL10497654 | 0.78 | CES2 (0.51) | KMT2AMEN1ALDH1A1LMNAMAPT | |
| SCHEMBL9204754 | 0.78 | LMNA (0.44) | CYP2D6BCHEACHECHRM1KMT2A | |
| SCHEMBL3647185 | 0.77 | KMT2A (0.46) | KMT2AMEN1ALDH1A1LMNAMAPT | |
| SCHEMBL10478280 | 0.76 | CYP2D6 (0.52) | CYP2D6BCHEACHECHRM1KMT2A | |
| SCHEMBL9203802 | 0.76 | BCHE (0.41) | CYP2D6BCHEACHEKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7423181-B2 | in particular against bacterial and parasitic infections, fungi, and helminths; improved metabolic and physiochemical properties, bioavailability, solubility; 3-[4-(2-Dimethylamino-ethoxy)-2'-trifluoromethyl-biphenyl-3-yl]-1-(2-dimethylaminomethyl-phenyl)-propenone | LICA PHARMACEUTICALS A/S (DK) | 2008-09-09 | — | — | US | disclosed |
| US-20050227990-A1 | Aminoalkoxy-functional chalcones | LICA PHARMACEUTICALS A/S (DK) | 2005-10-13 | — | — | US | disclosed |