Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 9/20 | 0.60 |
| ▸ | TAS1R1 | Q7RTX1 | 9/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 3/20 | 0.52 |
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.51 |
| ▸ | RELA | Q04206 | 1/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17822666 | 0.89 | TAS1R3 (0.62) | TAS1R3TAS1R1MEN1KMT2APKM | |
| SCHEMBL5407656 | 0.89 | TAS1R3 (0.62) | TAS1R3TAS1R1MEN1KMT2APKM | |
| SCHEMBL15787070 | 0.86 | TAS1R3 (0.60) | TAS1R3TAS1R1MEN1KMT2APKM | |
| SCHEMBL31611734 | 0.85 | TAS1R3 (0.78) | TAS1R3TAS1R1MEN1KMT2APKM | |
| SCHEMBL11142926 | 0.82 | TAS1R3 (0.67) | TAS1R3TAS1R1MEN1KMT2APKM | |
| SCHEMBL8874795 | 0.82 | MAPK9 (0.54) | TAS1R3TAS1R1MEN1KMT2APKM | |
| SCHEMBL8874793 | 0.82 | MAPK9 (0.54) | TAS1R3TAS1R1MEN1KMT2APKM | |
| SCHEMBL404332 | 0.81 | TAS1R3 (0.59) | TAS1R3TAS1R1MEN1KMT2APKM | |
| SCHEMBL5010361 | 0.79 | TAS1R3 (0.61) | TAS1R3TAS1R1MEN1KMT2APKM | |
| SCHEMBL25496973 | 0.79 | TAS1R3 (0.78) | TAS1R3TAS1R1MEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080176883-A1 | Antiinflammtory, antiproliferative, anticancer agents; (3-Hydroxy-pyrrolidin-1-yl)-(3-trifluoromethyl-7,8-dihydro-5H-[1,6]naphthyridin-6-yl)-methanone | ABBVIE INC. | 2008-07-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080176883-A1 | Antiinflammtory, antiproliferative, anticancer agents; (3-Hydroxy-pyrrolidin-1-yl)-(3-trifluoromethyl-7,8-dihydro-5H-[1,6]naphthyridin-6-yl)-methanone | MIF, CCL5, CCR2 | TAS1R3 1822/4885TAS1R1 1459/4885MEN1 3014/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.