Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 10/20 | 0.54 |
| ▸ | SLC6A2 | P23975 | 10/20 | 0.54 |
| ▸ | CHRNB4 | P30926 | 10/20 | 0.54 |
| ▸ | CHRNA3 | P32297 | 10/20 | 0.54 |
| ▸ | CHRNA4 | P43681 | 10/20 | 0.54 |
| ▸ | SLC6A3 | Q01959 | 10/20 | 0.54 |
| ▸ | CHRNA1 | P02708 | 9/20 | 0.54 |
| ▸ | CHRNB1 | P11230 | 9/20 | 0.54 |
| ▸ | CHRNG | P07510 | 8/20 | 0.54 |
| ▸ | CHRND | Q07001 | 8/20 | 0.54 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.54 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.40 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | CTSD | P07339 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15272219 | 0.82 | CHRNA1 (0.48) | CHRNB2SLC6A2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL4879907 | 0.79 | TAAR1 (0.41) | CHRNB2SLC6A2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL8990373 | 0.78 | CHRNB2 (0.46) | CHRNB2SLC6A2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL16097817 | 0.77 | ALOX5 (0.49) | CHRNB2SLC6A2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL23232243 | 0.76 | CHRNA1 (0.44) | CHRNB2SLC6A2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL30820875 | 0.76 | CHRNA1 (0.44) | CHRNB2SLC6A2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL23714901 | 0.75 | SLC6A2 (0.44) | CHRNB2SLC6A2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL23705341 | 0.73 | SLC6A2 (0.43) | CHRNB2SLC6A2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL16203267 | 0.73 | CHRNA1 (0.43) | CHRNB2SLC6A2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL7136098 | 0.73 | ALDH1A1 (0.42) | CHRNB2SLC6A2CHRNB4CHRNA3CHRNA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080280836-A1 | Anti-hypercholesterolemic biaryl azetidinone compounds | MORRIELLO GREGORI J | 2008-11-13 | — | — | US | disclosed |
| US-20080280836-A1 | Anti-hypercholesterolemic biaryl azetidinone compounds | MORRIELLO GREGORI J | 2008-11-13 | — | — | US | disclosed |
| US-20080280836-A1 | Anti-hypercholesterolemic biaryl azetidinone compounds | MORRIELLO GREGORI J | 2008-11-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080280836-A1 | Anti-hypercholesterolemic biaryl azetidinone compounds | APOB, PCSK9, CYP46A1 | CHRNB2 4722/4885SLC6A2 2282/4885CHRNB4 4827/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.