Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4876067 | 0.86 | ALDH1A1 (0.43) | ALDH1A1MAPTL3MBTL1TSHRNPC1 | |
| SCHEMBL4871718 | 0.74 | MAPT (0.39) | ALDH1A1MAPTKDM4ETSHRNPC1 | |
| SCHEMBL4885629 | 0.74 | TRPV4 (0.39) | TSHRSMN1; SMN2LMNA | |
| SCHEMBL4883499 | 0.73 | LMNA (0.37) | ALDH1A1MAPTLMNANPSR1 | |
| SCHEMBL4884645 | 0.67 | ALDH1A1 (0.46) | ALDH1A1NPC1SMN1; SMN2LMNA | |
| SCHEMBL7204676 | 0.66 | ALDH1A1 (0.77) | ALDH1A1MAPTL3MBTL1KDM4ETSHR | |
| SCHEMBL31588120 | 0.66 | ALDH1A1 (0.66) | ALDH1A1MAPTL3MBTL1KDM4ETSHR | |
| SCHEMBL13997417 | 0.64 | ALDH1A1 (0.68) | ALDH1A1MAPTL3MBTL1KDM4ETSHR | |
| SCHEMBL11151096 | 0.64 | ALDH1A1 (0.67) | ALDH1A1MAPTL3MBTL1KDM4ETSHR | |
| SCHEMBL1753713 | 0.64 | ALDH1A1 (0.62) | ALDH1A1MAPTL3MBTL1KDM4ETSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1799649-B1 | 3-(2-HYDROXYPHENYL) PYRAZOLES AND THEIR USE AS HSP90 MODULATORS | MERCK PATENT GMBH (DE) | 2014-06-25 | — | — | EP | disclosed |
| US-20080090880-A1 | 3-(2-Hydroxyphenyl) Pyrazoles and Thier Use as Hsp90 Modulators | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2008-04-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080090880-A1 | 3-(2-Hydroxyphenyl) Pyrazoles and Thier Use as Hsp90 Modulators | HSP90AB1, HSP90AA1, HSP90AB2P | ALDH1A1 1963/4885MAPT 2220/4885L3MBTL1 2152/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.