Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | ALPL | P05186 | 8/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4883703 | 0.85 | PTGS1 (0.39) | ALDH1A1POLBSMN1; SMN2RECQLPTGS1 | |
| SCHEMBL4885629 | 0.83 | TRPV4 (0.39) | SMN1; SMN2PTGS1PTGS2LMNA | |
| SCHEMBL4883499 | 0.82 | LMNA (0.37) | ALDH1A1PTGS1PTGS2LMNA | |
| SCHEMBL4882855 | 0.78 | THRB (0.41) | NPC1 | |
| SCHEMBL4881336 | 0.76 | ALDH1A1 (0.40) | ALDH1A1LMNA | |
| SCHEMBL4879852 | 0.75 | ALPL (0.46) | ALDH1A1ALPLNPC1LMNA | |
| SCHEMBL1628577 | 0.73 | RECQL (0.47) | ALDH1A1POLBSMN1; SMN2RECQLALPL | |
| SCHEMBL4881508 | 0.73 | KDM4E (0.44) | ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL4880103 | 0.72 | PFKFB3 (0.40) | ALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL4876502 | 0.71 | CYP1A2 (0.41) | ALDH1A1SMN1; SMN2ALPLNPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1799649-B1 | 3-(2-HYDROXYPHENYL) PYRAZOLES AND THEIR USE AS HSP90 MODULATORS | MERCK PATENT GMBH (DE) | 2014-06-25 | — | — | EP | disclosed |
| US-20080090880-A1 | 3-(2-Hydroxyphenyl) Pyrazoles and Thier Use as Hsp90 Modulators | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2008-04-17 | — | — | US | disclosed |
| CN-101035766-A | 3-(2-hydroxyphenyl) pyrazoles and their use as HSP90 modulators | MERCK PATENT GMBH (DE) | 2007-09-12 | — | — | CN | disclosed |
| EP-1799649-A1 | 3-(2-HYDROXYPHENYL) PYRAZOLES AND THEIR USE AS HSP90 MODULATORS | Merck Patent GmbH (DE) | 2007-06-27 | — | — | EP | disclosed |
| WO-2006039977-A1 | 3-(2-HYDROXYPHENYL) PYRAZOLES AND THEIR USE AS HSP90 MODULATORS | MERCK PATENT GMBH (DE) | 2006-04-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080090880-A1 | 3-(2-Hydroxyphenyl) Pyrazoles and Thier Use as Hsp90 Modulators | HSP90AB1, HSP90AA1, HSP90AB2P | ALDH1A1 1963/4885POLB 3543/4885SMN1; SMN2 3610/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.