Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | SLC12A2 | P55011 | 1/20 | 0.42 |
| ▸ | SLC12A5 | Q9H2X9 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TUBB | P07437 | 1/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4882855 | 0.85 | THRB (0.41) | P2RX4MAPTMCL1 | |
| SCHEMBL4880243 | 0.82 | GAA (0.39) | GAAP2RX4POLBTDP1 | |
| SCHEMBL4883703 | 0.81 | PTGS1 (0.39) | P2RX4SMN1; SMN2ALDH1A1POLB | |
| SCHEMBL4881336 | 0.81 | ALDH1A1 (0.40) | LMNAP2RX4MAPTALDH1A1 | |
| SCHEMBL4880023 | 0.80 | ACLY (0.45) | GAAMAPTSMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL4881508 | 0.80 | KDM4E (0.44) | LMNAGLASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL4880103 | 0.79 | PFKFB3 (0.40) | LMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL4879852 | 0.79 | ALPL (0.46) | LMNARAB9AALDH1A1TDP1 | |
| SCHEMBL4871718 | 0.78 | MAPT (0.39) | LMNAMAPTSMN1; SMN2KDM4ERAB9A | |
| SCHEMBL4876500 | 0.77 | MAPT (0.49) | LMNAGAAMAPTSMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1799649-B1 | 3-(2-HYDROXYPHENYL) PYRAZOLES AND THEIR USE AS HSP90 MODULATORS | MERCK PATENT GMBH (DE) | 2014-06-25 | — | — | EP | claimed |
| US-20080090880-A1 | 3-(2-Hydroxyphenyl) Pyrazoles and Thier Use as Hsp90 Modulators | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2008-04-17 | — | — | US | claimed |
| EP-1799649-A1 | 3-(2-HYDROXYPHENYL) PYRAZOLES AND THEIR USE AS HSP90 MODULATORS | Merck Patent GmbH (DE) | 2007-06-27 | — | — | EP | claimed |
| WO-2006039977-A1 | 3-(2-HYDROXYPHENYL) PYRAZOLES AND THEIR USE AS HSP90 MODULATORS | MERCK PATENT GMBH (DE) | 2006-04-20 | — | — | WO | claimed |
| EP-1799649-B1 | 3-(2-HYDROXYPHENYL) PYRAZOLES AND THEIR USE AS HSP90 MODULATORS | MERCK PATENT GMBH (DE) | 2014-06-25 | — | — | EP | disclosed |
| US-20080090880-A1 | 3-(2-Hydroxyphenyl) Pyrazoles and Thier Use as Hsp90 Modulators | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2008-04-17 | — | — | US | disclosed |
| EP-1799649-A1 | 3-(2-HYDROXYPHENYL) PYRAZOLES AND THEIR USE AS HSP90 MODULATORS | Merck Patent GmbH (DE) | 2007-06-27 | — | — | EP | disclosed |
| WO-2006039977-A1 | 3-(2-HYDROXYPHENYL) PYRAZOLES AND THEIR USE AS HSP90 MODULATORS | MERCK PATENT GMBH (DE) | 2006-04-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080090880-A1 | 3-(2-Hydroxyphenyl) Pyrazoles and Thier Use as Hsp90 Modulators | HSP90AB1, HSP90AA1, HSP90AB2P | LMNA 4229/4885SLC12A2 3087/4885SLC12A5 3443/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.