Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCKBR | P32239 | 16/20 | 1.00 |
| ▸ | CCKAR | P32238 | 13/20 | 1.00 |
| ▸ | ADRB2 | P07550 | 1/20 | 1.00 |
| ▸ | TSPO | P30536 | 1/20 | 1.00 |
| ▸ | GLP1R | P43220 | 1/20 | 1.00 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 1.00 |
| ▸ | PDE4A | P27815 | 2/20 | 0.64 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.64 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.64 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.64 |
| ▸ | PDE5A | O76074 | 1/20 | 0.64 |
| ▸ | PDE1A | P54750 | 1/20 | 0.64 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.64 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.64 |
| ▸ | GABRP | O00591 | 1/20 | 0.62 |
| ▸ | GABRD | O14764 | 1/20 | 0.62 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.62 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.62 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.62 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Devazepide SCHEMBL6255769 | 1.00 | CCKBR (1.00) | CCKBRCCKARADRB2TSPOGLP1R | |
| Devazepide SCHEMBL29406251 | 1.00 | CCKBR (1.00) | CCKBRCCKARADRB2TSPOGLP1R | |
| Devazepide SCHEMBL148766 | 1.00 | CCKBR (1.00) | CCKBRCCKARADRB2TSPOGLP1R | |
| Devazepide SCHEMBL31616311 | 1.00 | CCKBR (1.00) | CCKBRCCKARADRB2TSPOGLP1R | |
| Devazepide SCHEMBL8613468 | 1.00 | CCKBR (1.00) | CCKBRCCKARADRB2TSPOGLP1R | |
| SCHEMBL8437864 | 0.94 | CCKBR (0.88) | CCKBRCCKARADRB2TSPOGLP1R | |
| SCHEMBL9842437 | 0.94 | CCKBR (0.88) | CCKBRCCKARADRB2TSPOGLP1R | |
| SCHEMBL9422963 | 0.91 | CCKBR (0.83) | CCKBRCCKARADRB2TSPOGLP1R | |
| SCHEMBL7143510 | 0.90 | CCKBR (0.82) | CCKBRCCKARADRB2TSPOGLP1R | |
| SCHEMBL7143513 | 0.90 | CCKBR (0.82) | CCKBRCCKARADRB2TSPOGLP1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0167919-B1 | BENZODIAZEPINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | MERCK & CO. INC. (US) | 1993-05-05 | — | — | EP | claimed |
| EP-0284256-A1 | Benzodiazepine analogs | MERCK & CO. INC. (US) | 1988-09-28 | — | — | EP | claimed |
| EP-0167919-A2 | Benzodiazepine derivatives and pharmaceutical compositions containing them | MERCK & CO. INC. (US) | 1986-01-15 | — | — | EP | claimed |
| US-20080125414-A1 | Method of Treatment | PANOS THERAPEUTICS LIMITED (GB) | 2008-05-29 | — | — | US | disclosed |
| US-20080124741-A1 | Canine Cholecystokinin 1 Receptor Materials And Their Use | DAI HENG | 2008-05-29 | — | — | US | disclosed |
| EP-1492540-B1 | THE USE OF DEVAZEPIDE AS ANALGESIC AGENT | PANOS THERAPEUTICS LTD (GB) | 2007-10-17 | — | — | EP | disclosed |
| EP-1467718-B1 | METHOD OF TREATMENT OF A PATIENT REQUIRING ANALGESIA | ML LAB PLC (GB) | 2005-11-23 | — | — | EP | disclosed |
| US-20040198723-A1 | Method of treatment | ML LABORATORIES PLC (GB) | 2004-10-07 | — | — | US | disclosed |
| US-20040142959-A1 | Method of treatment | INNOVATA PLC (GB) | 2004-07-22 | — | — | US | disclosed |
| US-6713470-B2 | Method of treatment | ML LABORATORIES PLC (GB) | 2004-03-30 | — | — | US | disclosed |
| US-20040043990-A1 | Method of treatment | JACKSON KAREN (GB) | 2004-03-04 | — | — | US | disclosed |
| WO-1992000295-A1 | TETRAHYDROPYRIDOINDOLES AS CHOLECYSTOKININ AND GASTRIN ANTAGONISTS | RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) | 1992-01-09 | — | — | WO | disclosed |
| EP-0445976-A1 | Gamma emitting, CCK-A antagonists for pancreatic imaging | MERCK & CO. INC. (US) | 1991-09-11 | — | — | EP | disclosed |
| US-5004741-A | Cholecystokinin(CCK); Treating Disorders Of The Gastrointestinal Tract, Central Nervous System And Of The Appetite Of Animals | MERCK & CO., INC. (US) | 1991-04-02 | — | — | US | disclosed |
| US-4994258-A | Radiolabeled cholecystokinin-A antagonists bind to receptors | MERCK & CO., INC. (US) | 1991-02-19 | — | — | US | disclosed |
| US-4992437-A | Antisecretory, antiulcer agents | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1991-02-12 | — | — | US | disclosed |
| EP-0348523-A1 | THIENODIAZEPINE COMPOUNDS AND THEIR MEDICINAL USE | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1990-01-03 | — | — | EP | disclosed |
| US-4820834-A | Benzodiazepine analogs | MERCK & CO., INC. (US) | 1989-04-11 | — | — | US | disclosed |
| EP-0284256-A1 | Benzodiazepine analogs | MERCK & CO. INC. (US) | 1988-09-28 | — | — | EP | disclosed |
| EP-0167919-A2 | Benzodiazepine derivatives and pharmaceutical compositions containing them | MERCK & CO. INC. (US) | 1986-01-15 | — | — | EP | disclosed |