Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCKBR | P32239 | 16/20 | 1.00 |
| ▸ | CCKAR | P32238 | 13/20 | 1.00 |
| ▸ | ADRB2 | P07550 | 1/20 | 1.00 |
| ▸ | TSPO | P30536 | 1/20 | 1.00 |
| ▸ | GLP1R | P43220 | 1/20 | 1.00 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 1.00 |
| ▸ | PDE4A | P27815 | 2/20 | 0.64 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.64 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.64 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.64 |
| ▸ | PDE5A | O76074 | 1/20 | 0.64 |
| ▸ | PDE1A | P54750 | 1/20 | 0.64 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.64 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.64 |
| ▸ | GABRP | O00591 | 1/20 | 0.62 |
| ▸ | GABRD | O14764 | 1/20 | 0.62 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.62 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.62 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.62 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Devazepide SCHEMBL4884074 | 1.00 | CCKBR (1.00) | CCKBRCCKARADRB2TSPOGLP1R | |
| Devazepide SCHEMBL6255769 | 1.00 | CCKBR (1.00) | CCKBRCCKARADRB2TSPOGLP1R | |
| Devazepide SCHEMBL29406251 | 1.00 | CCKBR (1.00) | CCKBRCCKARADRB2TSPOGLP1R | |
| Devazepide SCHEMBL148766 | 1.00 | CCKBR (1.00) | CCKBRCCKARADRB2TSPOGLP1R | |
| Devazepide SCHEMBL31616311 | 1.00 | CCKBR (1.00) | CCKBRCCKARADRB2TSPOGLP1R | |
| SCHEMBL8437864 | 0.94 | CCKBR (0.88) | CCKBRCCKARADRB2TSPOGLP1R | |
| SCHEMBL9842437 | 0.94 | CCKBR (0.88) | CCKBRCCKARADRB2TSPOGLP1R | |
| SCHEMBL9422963 | 0.91 | CCKBR (0.83) | CCKBRCCKARADRB2TSPOGLP1R | |
| SCHEMBL7143510 | 0.90 | CCKBR (0.82) | CCKBRCCKARADRB2TSPOGLP1R | |
| SCHEMBL7143513 | 0.90 | CCKBR (0.82) | CCKBRCCKARADRB2TSPOGLP1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5817658-A | ADMINISTERING A DIAZEPINE COMPOUND; DISEASES OF THE EAR | MERCK & COMPANY, INC. (US) | 1998-10-06 | — | — | US | disclosed |
| US-5776930-A | CARDIOVASCULAR DISORDERS | MERCK & COMPANY, INC. (US) | 1998-07-07 | — | — | US | disclosed |
| US-5597818-A | CARDIOVASCULAR DISORDERS | MERCK & CO., INC. (US) | 1997-01-28 | — | — | US | disclosed |
| US-5595990-A | TREATMENT OF CARDIOVASCULAR DISORDERS | MERCK & CO., INC. (US) | 1997-01-21 | — | — | US | disclosed |
| EP-0445976-B1 | Gamma emitting, CCK-A antagonists for pancreatic imaging | MERCK & CO INC (US) | 1996-05-01 | — | — | EP | disclosed |
| US-5428031-A | Benzodiazepine analogs; cardiovascular disorders | MERCK & CO., INC. (US) | 1995-06-27 | — | — | US | disclosed |
| US-5426185-A | Antiarrhythmia agents having reduced side effects | MERCK & CO., INC. (US) | 1995-06-20 | — | — | US | disclosed |
| WO-1995014471-A1 | ANTIARRHYTHMIC BENZODIAZEPINES | MERCK & CO., INC. (US) | 1995-06-01 | — | — | WO | disclosed |
| EP-0445976-A1 | Gamma emitting, CCK-A antagonists for pancreatic imaging | MERCK & CO. INC. (US) | 1991-09-11 | — | — | EP | disclosed |
| US-4994258-A | Radiolabeled cholecystokinin-A antagonists bind to receptors | MERCK & CO., INC. (US) | 1991-02-19 | — | — | US | disclosed |