Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | CES2 | O00748 | 1/20 | 0.57 |
| ▸ | CES1 | P23141 | 1/20 | 0.57 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.57 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.57 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.57 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.57 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.57 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.57 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.57 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.57 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.57 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.57 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.57 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28188567 | 0.97 | PDE4B (0.67) | PDE4BALDH1A1CYP1A2HPGDCYP2C19 | |
| SCHEMBL4722288 | 0.90 | ALDH1A1 (0.69) | PDE4BALDH1A1CYP1A2HPGDCYP2C19 | |
| SCHEMBL30416831 | 0.90 | ALDH1A1 (0.69) | PDE4BALDH1A1CYP1A2HPGDCYP2C19 | |
| SCHEMBL7315752 | 0.86 | THRA (0.60) | CES2CES1HDAC3HDAC4HDAC1 | |
| SCHEMBL4884718 | 0.86 | THRA (0.60) | CES2CES1HDAC3HDAC4HDAC1 | |
| SCHEMBL10736335 | 0.86 | THRA (0.60) | CES2CES1HDAC3HDAC4HDAC1 | |
| SCHEMBL7389569 | 0.86 | CES2 (0.56) | ALDH1A1CES2CES1HSD11B1CTNNB1 | |
| SCHEMBL4889161 | 0.86 | CES2 (0.56) | ALDH1A1CES2CES1HSD11B1CTNNB1 | |
| SCHEMBL4638591 | 0.86 | CES2 (0.59) | CES2CES1HDAC3HDAC4HDAC1 | |
| SCHEMBL8269548 | 0.85 | HSD11B1 (0.64) | ALDH1A1CYP1A2HPGDCYP2C19HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080262011-A1 | Modulator | UCL BIOMEDICA PLC (GB) | 2008-10-23 | — | — | US | disclosed |
| US-20080262011-A1 | Modulator | UCL BIOMEDICA PLC (GB) | 2008-10-23 | — | — | US | disclosed |
| US-20080262011-A1 | Modulator | UCL BIOMEDICA PLC (GB) | 2008-10-23 | — | — | US | disclosed |
| EP-1853538-A2 | MODULATOR | UCL Biomedica plc (GB) | 2007-11-14 | — | — | EP | disclosed |
| WO-2006067450-A2 | MODULATOR | UCL BIOMEDICA PLC (GB) | 2006-06-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080262011-A1 | Modulator | CHRNA10, CNR1, CHRNA9 | PDE4B 2342/4885ALDH1A1 3671/4885CYP1A2 547/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.