Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19782876 | 0.78 | GSK3B (0.54) | LMNAALDH1A1HSD17B10KDM4EHPGD | |
| SCHEMBL2705086 | 0.78 | BRD4 (0.48) | BRD4LMNAALDH1A1HSD17B10KDM4E | |
| SCHEMBL6759202 | 0.77 | BRD4 (0.60) | BRD4ALDH1A1HSD17B10KDM4EHTT | |
| SCHEMBL4886179 | 0.77 | ALDH1A1 (0.44) | BRD4LMNAALDH1A1HSD17B10KDM4E | |
| SCHEMBL21367067 | 0.76 | ALDH1A1 (0.37) | BRD4LMNAALDH1A1HSD17B10KDM4E | |
| SCHEMBL13240400 | 0.73 | KMT2A (0.51) | LMNAALDH1A1TSHRMEN1KMT2A | |
| SCHEMBL4882694 | 0.72 | MAPT (0.52) | BRD4LMNAALDH1A1HSD17B10KDM4E | |
| SCHEMBL18311966 | 0.71 | ALDH1A1 (0.52) | LMNAALDH1A1HSD17B10KDM4EHPGD | |
| SCHEMBL3055229 | 0.70 | ALDH1A1 (0.46) | LMNAALDH1A1HTTL3MBTL1TSHR | |
| SCHEMBL19782990 | 0.70 | BRD4 (0.45) | BRD4LMNAALDH1A1HSD17B10KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080167324-A1 | Thiazolymethyl and Oxazolylmethyl Heteroaryl Derivatives | NEUROGEN CORPORATION | 2008-07-10 | — | — | US | disclosed |
| US-20080167324-A1 | Thiazolymethyl and Oxazolylmethyl Heteroaryl Derivatives | NEUROGEN CORPORATION | 2008-07-10 | — | — | US | disclosed |
| US-20080167324-A1 | Thiazolymethyl and Oxazolylmethyl Heteroaryl Derivatives | NEUROGEN CORPORATION | 2008-07-10 | — | — | US | disclosed |
| WO-2006093911-A2 | THIAZOLYLMETHYL AND OXAZOLYLMETHYL HETEROARYL DERIVATIVES | NEUROGEN CORPORATION (US) | 2006-09-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080167324-A1 | Thiazolymethyl and Oxazolylmethyl Heteroaryl Derivatives | GABBR1, GABBR2, GABRA3 | BRD4 2966/4885LMNA 4070/4885ALDH1A1 309/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.