Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | AGER | Q15109 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.36 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20626775 | 0.85 | EGLN2 (0.46) | ALDH1A1SMN1; SMN2LMNAL3MBTL1KDM4E | |
| SCHEMBL4884948 | 0.76 | BRD4 (0.41) | ALDH1A1SMN1; SMN2LMNAL3MBTL1KDM4E | |
| SCHEMBL24663483 | 0.73 | P2RX7 (0.42) | ALDH1A1SMN1; SMN2LMNAL3MBTL1KDM4E | |
| SCHEMBL5313640 | 0.73 | ALDH1A1 (0.45) | ALDH1A1SMN1; SMN2L3MBTL1KDM4EMAPT | |
| SCHEMBL29543454 | 0.73 | ALDH1A1 (0.45) | ALDH1A1SMN1; SMN2L3MBTL1KDM4EMAPT | |
| SCHEMBL21581227 | 0.73 | EGLN2 (0.44) | ALDH1A1LMNAL3MBTL1KDM4EMAPT | |
| SCHEMBL8866011 | 0.73 | KDM4E (0.47) | ALDH1A1SMN1; SMN2L3MBTL1KDM4EMAPT | |
| SCHEMBL6759202 | 0.72 | BRD4 (0.60) | ALDH1A1SMN1; SMN2L3MBTL1KDM4EMAPT | |
| SCHEMBL2657576 | 0.72 | APOBEC3A (0.45) | ALDH1A1LMNAL3MBTL1MAPTHPGD | |
| SCHEMBL19578168 | 0.71 | GSK3B (0.58) | ALDH1A1SMN1; SMN2LMNAL3MBTL1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019177873-A1 | ARGINASE INHIBITORS AND METHODS OF USE | MERCK SHARP & DOHME CORP. (US) | 2019-09-19 | — | — | WO | disclosed |