Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 11/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.35 |
| ▸ | HPGD | P15428 | 4/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | APEX1 | P27695 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | TOP2A | P11388 | 4/20 | 0.33 |
| ▸ | TOP1 | P11387 | 3/20 | 0.33 |
| ▸ | AADAT | Q8N5Z0 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ALB | P02768 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4884272 | 0.94 | KDM4E (0.36) | KDM4EADRA2BMAPK1ALDH1A1HPGD | |
| Trifluoroacetic Acid SCHEMBL4183630 | 0.77 | KDM4E (0.34) | KDM4EADRA2BMAPK1ALDH1A1HPGD | |
| SCHEMBL4134055 | 0.72 | KDM4E (0.39) | KDM4EADRA2BMAPK1ALDH1A1HPGD | |
| SCHEMBL4879429 | 0.72 | ALDH1A1 (0.34) | KDM4EMAPK1ALDH1A1HPGDHSD17B10 | |
| SCHEMBL4154463 | 0.72 | KDM4E (0.38) | KDM4EADRA2BMAPK1ALDH1A1HPGD | |
| SCHEMBL8908261 | 0.72 | KDM4E (0.48) | KDM4EADRA2BMAPK1ALDH1A1HPGD | |
| SCHEMBL30542871 | 0.71 | KDM4E (0.46) | KDM4EADRA2BMAPK1ALDH1A1HPGD | |
| SCHEMBL26363246 | 0.71 | KDM4E (0.46) | KDM4EADRA2BMAPK1ALDH1A1HPGD | |
| SCHEMBL2183758 | 0.69 | MCL1 (0.49) | KDM4ELMNA | |
| Hydrochloric Acid SCHEMBL4129204 | 0.68 | KDM4E (0.64) | KDM4EALDH1A1HPGDHSD17B10CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080096829-A1 | Macrolone Compounds | GLAXO GROUP LIMITED (GB) | 2008-04-24 | — | — | US | disclosed |
| US-20080096829-A1 | Macrolone Compounds | GLAXO GROUP LIMITED (GB) | 2008-04-24 | — | — | US | disclosed |
| US-20080096829-A1 | Macrolone Compounds | GLAXO GROUP LIMITED (GB) | 2008-04-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080096829-A1 | Macrolone Compounds | MRPL21, MRPS18A, MRPL19 | KDM4E 4136/4885ADRA2B 2848/4885MAPK1 2012/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.