Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.34 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | TOP2A | P11388 | 11/20 | 0.34 |
| ▸ | TOP1 | P11387 | 5/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | APEX1 | P27695 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | AADAT | Q8N5Z0 | 2/20 | 0.33 |
| ▸ | TOP2B | Q02880 | 7/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL3976871 | 0.84 | KDM4E (0.38) | KDM4EADRA2BMAPK1ALDH1A1HPGD | |
| SCHEMBL4178090 | 0.78 | SIGMAR1 (0.37) | ALDH1A1CYP1A2CYP2D6 | |
| Trifluoroacetic Acid SCHEMBL4164839 | 0.77 | KDM4E (0.35) | KDM4EADRA2BMAPK1TOP2ATOP1 | |
| SCHEMBL4886189 | 0.77 | KDM4E (0.35) | KDM4EADRA2BMAPK1TOP2ATOP1 | |
| SCHEMBL4175956 | 0.75 | KDM4E (0.37) | KDM4EADRA2BMAPK1TOP2ATOP1 | |
| Trifluoroacetic Acid SCHEMBL4146945 | 0.73 | KDM4E (0.39) | KDM4EADRA2BMAPK1TOP1ALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL4175924 | 0.72 | KDM4E (0.42) | KDM4ETOP2AALDH1A1HPGDHSD17B10 | |
| SCHEMBL4879938 | 0.72 | CNR1 (0.41) | KDM4ETOP2ATOP1ALDH1A1HPGD | |
| Hydrochloric Acid SCHEMBL3288995 | 0.72 | KDM4E (0.48) | KDM4ETOP2ATOP1ALDH1A1HPGD | |
| Trifluoroacetic Acid SCHEMBL4172149 | 0.72 | KDM4E (0.35) | KDM4EADRA2BMAPK1TOP2ATOP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090062218-A1 | MACROLONE COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2009-03-05 | — | — | US | disclosed |
| US-20080096829-A1 | Macrolone Compounds | GLAXO GROUP LIMITED (GB) | 2008-04-24 | — | — | US | disclosed |
| EP-1824497-A1 | MACROLONE COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2007-08-29 | — | — | EP | disclosed |
| WO-2006050943-A1 | MACROLONE COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2006-05-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090062218-A1 | MACROLONE COMPOUNDS | CYP51A1, MRPL21, MYD88 | KDM4E 3897/4885ADRA2B 2901/4885MAPK1 1945/4885 |
| US-20080096829-A1 | Macrolone Compounds | MRPL21, MRPS18A, MRPL19 | KDM4E 4136/4885ADRA2B 2848/4885MAPK1 2012/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.