Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 7/20 | 0.50 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.50 |
| ▸ | SPHK1 | Q9NYA1 | 2/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | GMNN | O75496 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | THPO | P40225 | 1/20 | 0.42 |
| ▸ | MTOR | P42345 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | CETP | P11597 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | UBE2N | P61088 | 1/20 | 0.42 |
| ▸ | LAP3 | P28838 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28086869 | 0.82 | — | — | |
| SCHEMBL1876621 | 0.82 | — | — | |
| Hydrochloric Acid SCHEMBL28275255 | 0.80 | — | — | |
| SCHEMBL12019016 | 0.78 | OPRM1 (0.44) | GPR84SPHK1OPRM1CYP2D6LMNA | |
| SCHEMBL723124 | 0.78 | GPR84 (0.58) | GPR84FFAR1SPHK1OPRM1CYP2D6 | |
| SCHEMBL1291102 | 0.76 | GPR84 (0.61) | GPR84FFAR1SPHK1TP53MAPT | |
| SCHEMBL19032390 | 0.76 | CA1 (0.50) | SPHK1OPRM1CYP2D6LMNATP53 | |
| SCHEMBL8021744 | 0.76 | OPRM1 (0.48) | SPHK1OPRM1CYP2D6LMNATP53 | |
| SCHEMBL6048498 | 0.76 | GPR84 (0.61) | GPR84FFAR1SPHK1CYP2D6LMNA | |
| SCHEMBL23578543 | 0.74 | GPR84 (0.54) | GPR84FFAR1SPHK1OPRM1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102653520-A | Preparation method of 2-hydroxy-2-aryl thioacetamide | UNIV SOOCHOW | 2012-09-05 | — | — | CN | claimed |
| US-8273412-B2 | Method for applying corrosion protection layers comprising thioamides to metallic surfaces | BASF AKTIENGESELLSCHAFT (DE) | 2012-09-25 | — | — | US | disclosed |
| CN-102653520-A | Preparation method of 2-hydroxy-2-aryl thioacetamide | UNIV SOOCHOW | 2012-09-05 | — | — | CN | disclosed |
| CN-102653520-A | Preparation method of 2-hydroxy-2-aryl thioacetamide | UNIV SOOCHOW | 2012-09-05 | — | — | CN | disclosed |
| CN-102653520-A | Preparation method of 2-hydroxy-2-aryl thioacetamide | UNIV SOOCHOW | 2012-09-05 | — | — | CN | disclosed |
| US-20080131687-A1 | Method For Applying Corrosion Protection Layers Comprising Thioamides To Metallic Surfaces | BASF AKTIENGESELLSCHAFT (DE) | 2008-06-05 | — | — | US | disclosed |
| EP-0765321-B1 | 2-AMINO-3-AROYL-BENZO BETA THIOPHENES AND METHOD OF MAKING THE SAME | LILLY CO ELI (US) | 2001-04-18 | — | — | EP | disclosed |
| EP-0764150-B1 | PRODUCTION OF HYDROXYTHIOACETAMIDES AND USE THEREOF IN THE SYNTHESIS OF BENZOTHIOPHENES | LILLY CO ELI (US) | 1999-10-27 | — | — | EP | disclosed |
| US-5792870-A | 2-amino-3-aroyl-benzo β!thiophenes and methods for preparing and using same to produce 6-hdyroxy-2-(4-hydroxyphenyl)-3- 4-(2-aminoethoxy)-benzoyl!benzo β!thiophenes | ELI LILLY AND COMPANY (US) | 1998-08-11 | — | — | US | disclosed |
| EP-0764150-A4 | PRODUCTION OF HYDROXYTHIOACETAMIDES AND USE THEREOF IN THE SYNTHESIS OF BENZOTHIOPHENES | LILLY CO ELI (US) | 1997-09-10 | — | — | EP | disclosed |
| EP-0765321-A4 | — | — | 1997-05-02 | — | — | EP | disclosed |
| EP-0765321-A1 | 2-AMINO-3-AROYL-BENZO BETA THIOPHENES AND METHOD OF MAKING THE SAME | ELI LILLY AND COMPANY (US) | 1997-04-02 | — | — | EP | disclosed |
| EP-0764150-A1 | PRODUCTION OF HYDROXYTHIOACETAMIDES AND USE THEREOF IN THE SYNTHESIS OF BENZOTHIOPHENES | ELI LILLY AND COMPANY (US) | 1997-03-26 | — | — | EP | disclosed |
| US-5554755-A | 2-amino-3-aroyl-benzo[β]thiophenes and methods for preparing and using same to produce 6-hydroxy-2-(4-hydroxyphenyl)-3-[4-(2-aminoethoxy)-benzoyl]benzo[β]thiophenes | ELI LILLY AND COMPANY (US) | 1996-09-10 | — | — | US | disclosed |
| WO-1995034536-A1 | PRODUCTION OF HYDROXYTHIOACETAMIDES AND USE THEREOF IN THE SYNTHESIS OF BENZOTHIOPHENES | ELI LILLY AND COMPANY (US) | 1995-12-21 | — | — | WO | disclosed |
| US-5466810-A | 2-amino-3-aroyl-benzo[β]thiophenes and methods for preparing and using same to produce 6-hydroxy-2-(4-hydroxyphenyl)-3-[4-(2-aminoethoxy)-benzoyl]benzo[β]thiophenes | ELI LILLY AND COMPANY (US) | 1995-11-14 | — | — | US | disclosed |
| US-5420349-A | 2-amino-3-aroyl-benzo[β]thiophenes and methods for preparing and using same to produce 6-hydroxy-2-(4-hydroxyphenyl)-3-]benzo[4-(2-aminoethoxy)-benzoyl[β]thiophenes | ELI LILLY AND COMPANY (US) | 1995-05-30 | — | — | US | disclosed |