Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.46 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.43 |
| ▸ | F2 | P00734 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CES2 | O00748 | 1/20 | 0.42 |
| ▸ | CES1 | P23141 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL487361 | 1.00 | DPP4 (0.54) | DPP4LMNAMAPK1EPHX1BCAT2 | |
| SCHEMBL487568 | 1.00 | DPP4 (0.54) | DPP4LMNAMAPK1EPHX1BCAT2 | |
| SCHEMBL4744699 | 1.00 | DPP4 (0.54) | DPP4LMNAMAPK1EPHX1BCAT2 | |
| SCHEMBL487880 | 1.00 | DPP4 (0.54) | DPP4LMNAMAPK1EPHX1BCAT2 | |
| SCHEMBL4884477 | 1.00 | DPP4 (0.54) | DPP4LMNAMAPK1EPHX1BCAT2 | |
| Hydrochloric Acid SCHEMBL487925 | 0.98 | DPP4 (0.52) | DPP4LMNAMAPK1EPHX1BCAT2 | |
| SCHEMBL939042 | 0.84 | DPP4 (0.56) | DPP4LMNAMAPK1ADRA2AADRA2C | |
| SCHEMBL8058962 | 0.84 | DPP4 (0.56) | DPP4LMNAMAPK1ADRA2AADRA2C | |
| SCHEMBL5860807 | 0.84 | DPP4 (0.56) | DPP4LMNAMAPK1ADRA2AADRA2C | |
| SCHEMBL4073511 | 0.84 | DPP4 (0.56) | DPP4LMNAMAPK1ADRA2AADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5663393-A | CYCLIZATION; DECYCLIZATION; HYDROLYSIS; HYDROGENATION | RESEARCH CORPORATION TECHNOLOGIES, INC. (US) | 1997-09-02 | — | — | US | claimed |
| EP-0643626-A4 | CHIRAL CATALYSTS, CATALYTIC OXIDATION AND DISPROPORTIONATION REACTIONS, AND METHODS OF PRODUCING EPOXYCHROMANS AND TAXOL. | RES CORP TECHNOLOGIES INC (US) | 1995-12-06 | — | — | EP | claimed |
| EP-0643626-A1 | CHIRAL CATALYSTS, CATALYTIC OXIDATION AND DISPROPORTIONATION REACTIONS, AND METHODS OF PRODUCING EPOXYCHROMANS AND TAXOL | RESEARCH CORPORATION TECHNOLOGIES, INC. (US) | 1995-03-22 | — | — | EP | claimed |
| WO-1993003838-A1 | CHIRAL CATALYSTS, CATALYTIC OXIDATION AND DISPROPORTIONATION REACTIONS, AND METHODS OF PRODUCING EPOXYCHROMANS AND TAXOL | RESEARCH CORPORATION TECHNOLOGIES, INC. (US) | 1993-03-04 | — | — | WO | claimed |
| US-20080249310-A1 | Process For the Preparation of (2R,3R)-2-Hydroxy-3-Amino-3-Aryl-Propionamide and (2R,3R)-2-Hydroxy-3-Amino-3-Aryl-Propionic Acid Alkyl Ester | DSM IP ASSETS B.V. (NL) | 2008-10-09 | — | — | US | disclosed |
| EP-1831150-A1 | PROCESS FOR THE PREPARATION OF (2R, 3R)-2-HYDROXY-3-AMINO-3-ARYL-PROPIONAMIDE AND (2R, 3R)-2-HYDROXY-3-AMINO-3-ARYL-PROPIONIC ACID ALKYL ESTER | DSMIP Assets B.V. (NL) | 2007-09-12 | — | — | EP | disclosed |
| CN-101035537-A | Compositions and methods for treating ocular diseases | MERCK & CO INC (US) | 2007-09-12 | — | — | CN | disclosed |
| CN-101027277-A | Process for the preparation of (2R, 3R)-2-hydroxy-3-amino-3-aryl-propionamide and (2R, 3R)-2-hydroxy-3-amino-3-aryl-propionic acid alkylester | DSM IP ASSETS BV (NL) | 2007-08-29 | — | — | CN | disclosed |
| WO-2006008170-A1 | PROCESS FOR THE PREPARATION OF (2R, 3R)-2-HYDROXY-3-AMINO-3-ARYL-PROPIONAMIDE AND (2R, 3R)-2-HYDROXY-3-AMINO-3-ARYL-PROPIONIC ACID ALKYL ESTER | DSM IP ASSETS B.V. (NL) | 2006-01-26 | — | — | WO | disclosed |
| EP-0643626-B1 | METHOD OF PRODUCING EPOXYCHROMANS WITH A CHIRAL CATALYST | RES CORP TECHNOLOGIES INC (US) | 2002-02-27 | — | — | EP | disclosed |
| US-6025516-A | Resolution of 2-hydroxy-3-amino-3-phenylpropionamide and its conversion to C-13 sidechain of taxanes | CHIRAGENE, INC. (US) | 2000-02-15 | — | — | US | disclosed |
| US-6025516-A | Resolution of 2-hydroxy-3-amino-3-phenylpropionamide and its conversion to C-13 sidechain of taxanes | CHIRAGENE, INC. (US) | 2000-02-15 | — | — | US | disclosed |
| US-6025516-A | Resolution of 2-hydroxy-3-amino-3-phenylpropionamide and its conversion to C-13 sidechain of taxanes | CHIRAGENE, INC. (US) | 2000-02-15 | — | — | US | disclosed |
| US-5663393-A | CYCLIZATION; DECYCLIZATION; HYDROLYSIS; HYDROGENATION | RESEARCH CORPORATION TECHNOLOGIES, INC. (US) | 1997-09-02 | — | — | US | disclosed |
| US-5637739-A | ORGANOMETALLIC CATALYSTS FOR ENANTIOSELECTIVELY EPOXIDIZING PROCHIRAL OLEFINS | RESEARCH CORPORATION TECHNOLOGIES, INC. (US) | 1997-06-10 | — | — | US | disclosed |
| EP-0643626-A4 | CHIRAL CATALYSTS, CATALYTIC OXIDATION AND DISPROPORTIONATION REACTIONS, AND METHODS OF PRODUCING EPOXYCHROMANS AND TAXOL. | RES CORP TECHNOLOGIES INC (US) | 1995-12-06 | — | — | EP | disclosed |
| EP-0643626-A1 | CHIRAL CATALYSTS, CATALYTIC OXIDATION AND DISPROPORTIONATION REACTIONS, AND METHODS OF PRODUCING EPOXYCHROMANS AND TAXOL | RESEARCH CORPORATION TECHNOLOGIES, INC. (US) | 1995-03-22 | — | — | EP | disclosed |
| WO-1993003838-A1 | CHIRAL CATALYSTS, CATALYTIC OXIDATION AND DISPROPORTIONATION REACTIONS, AND METHODS OF PRODUCING EPOXYCHROMANS AND TAXOL | RESEARCH CORPORATION TECHNOLOGIES, INC. (US) | 1993-03-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080249310-A1 | Process For the Preparation of (2R,3R)-2-Hydroxy-3-Amino-3-Aryl-Propionamide and (2R,3R)-2-Hydroxy-3-Amino-3-Aryl-Propionic Acid Alkyl Ester | GRHPR, B3GAT3, HCAR3 | DPP4 479/4885LMNA 1245/4885MAPK1 1945/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.