Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SHBG | P04278 | 2/20 | 0.54 |
| ▸ | ATP1A1 | P05023 | 1/20 | 0.37 |
| ▸ | ATP1B1 | P05026 | 1/20 | 0.37 |
| ▸ | ATP1A3 | P13637 | 1/20 | 0.37 |
| ▸ | ATP1B2 | P14415 | 1/20 | 0.37 |
| ▸ | ATP1A2 | P50993 | 1/20 | 0.37 |
| ▸ | ATP1B3 | P54709 | 1/20 | 0.37 |
| ▸ | FXYD2 | P54710 | 1/20 | 0.37 |
| ▸ | ATP1A4 | Q13733 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.34 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.34 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.34 |
| ▸ | EFNA1 | P20827 | 1/20 | 0.34 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.34 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.34 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.34 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11793890 | 0.88 | SHBG (0.51) | SHBGATP1A1ATP1B1ATP1A3ATP1B2 | |
| SCHEMBL11793885 | 0.88 | SHBG (0.51) | SHBGATP1A1ATP1B1ATP1A3ATP1B2 | |
| SCHEMBL2010128 | 0.85 | SHBG (0.53) | SHBGHSD17B10KMT2AGPBAR1LMNA | |
| SCHEMBL9223384 | 0.84 | SHBG (0.48) | SHBGATP1A1ATP1B1ATP1A3ATP1B2 | |
| SCHEMBL5856187 | 0.83 | SHBG (0.44) | SHBGATP1A1ATP1B1ATP1A3ATP1B2 | |
| SCHEMBL5856182 | 0.83 | SHBG (0.44) | SHBGATP1A1ATP1B1ATP1A3ATP1B2 | |
| SCHEMBL10794999 | 0.82 | SHBG (0.39) | SHBGATP1A1ATP1B1ATP1A3ATP1B2 | |
| SCHEMBL1331512 | 0.82 | CYP19A1 (0.47) | SHBGATP1A1ATP1B1ATP1A3ATP1B2 | |
| SCHEMBL11520209 | 0.82 | CYP19A1 (0.47) | SHBGATP1A1ATP1B1ATP1A3ATP1B2 | |
| SCHEMBL1868110 | 0.80 | NR3C1 (0.53) | SHBGHSD17B10KMT2AGPBAR1HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080033046-A1 | Treatment of myocardial infarction with 11HSD1 inhibitors | UNIVERSITY OF EDINBURGH (GB) | 2008-02-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080033046-A1 | Treatment of myocardial infarction with 11HSD1 inhibitors | HSD11B1, HSD11B2, CYP11B1 | SHBG 1208/4885ATP1A1 1517/4885ATP1B1 2032/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.