SCHEMBL4887307

SCHEMBL4887307

CC(C)(C)[C@H](NC(=O)[C@H](CC1CCCC1)CN(O)C=O)C(=O)N1CCC(NC(=O)Cc2ccccc2)CC1

nearest known ligand 0.45

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
MMP1 P03956 6/20 0.45
MMP13 P45452 3/20 0.45
MMP2 P08253 8/20 0.45
MMP3 P08254 4/20 0.45
MEN1 O00255 1/20 0.43
KMT2A Q03164 1/20 0.43
EPHX2 P34913 1/20 0.41
SIGMAR1 Q99720 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4602474 0.90 MMP1 (0.44) MMP1MMP13MMP2MMP3MEN1
SCHEMBL6135717 0.89 MMP1 (0.48) MMP1MMP13MMP2MMP3MEN1
SCHEMBL6135501 0.89 MMP1 (0.48) MMP1MMP13MMP2MMP3MEN1
SCHEMBL6135720 0.89 MMP1 (0.48) MMP1MMP13MMP2MMP3MEN1
SCHEMBL6135506 0.89 MMP1 (0.48) MMP1MMP13MMP2MMP3MEN1
SCHEMBL14066495 0.89 MMP2 (0.45) MMP2MMP3MEN1KMT2A
SCHEMBL2795037 0.88 MMP1 (0.45) MMP1MMP13MMP2MMP3
SCHEMBL2795032 0.88 MMP1 (0.45) MMP1MMP13MMP2MMP3
SCHEMBL4880579 0.86 MMP2 (0.59) MMP1MMP13MMP2MMP3
SCHEMBL4603007 0.85 NPC1 (0.41) MMP1MMP13MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080234333-A1 Novel Hydroxamic Acid Derivative as Peptide Deformylase Inhibitor and Manufacturing Method Thereof KANG JAE-HOON 2008-09-25 US disclosed
US-20080234333-A1 Novel Hydroxamic Acid Derivative as Peptide Deformylase Inhibitor and Manufacturing Method Thereof KANG JAE-HOON 2008-09-25 US disclosed
US-20080234333-A1 Novel Hydroxamic Acid Derivative as Peptide Deformylase Inhibitor and Manufacturing Method Thereof KANG JAE-HOON 2008-09-25 US disclosed
WO-2006115353-A9 A NOVEL HYDROXAMIC ACID DERIVATIVE AS PEPTIDE DEFORMYLASE INHIBITOR AND MANUFACTURING METHOD THEREOF ILDONG PHARMACEUTICAL CO LTD (KR) 2007-03-22 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080234333-A1 Novel Hydroxamic Acid Derivative as Peptide Deformylase Inhibitor and Manufacturing Method Thereof PDF, PEPD, DHPS MMP1 885/4885MMP13 740/4885MMP2 315/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.